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A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

Lundwall, Åke LU and Lazure, C. (1995) In FEBS Letters 374(1). p.6-53
Abstract
Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
Please use this url to cite or link to this publication:
author
and
organization
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type
Contribution to journal
publication status
published
subject
keywords
*Prostatic Secretory Proteins, *Multigene Family, Molecular Sequence Data, Male, Humans, Guinea Pigs, Gonadal Steroid Hormones/genetics, *Exons, Molecular, *Evolution, Dna, Conserved Sequence, Animals, Base Sequence, Proteins/*genetics, Rats, Research Support, Non-U.S. Gov't, *Semen, Seminal Plasma Proteins, Seminal Vesicle Secretory Proteins, Sequence Homology, Nucleic Acid
in
FEBS Letters
volume
374
issue
1
pages
6 - 53
publisher
Wiley-Blackwell
external identifiers
  • scopus:0028788899
ISSN
1873-3468
language
English
LU publication?
yes
additional info
1
id
1a4a9e65-0dda-4fbb-8639-401772da7f90 (old id 3965233)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7589511
date added to LUP
2016-04-04 13:05:11
date last changed
2021-01-03 05:02:45
@article{1a4a9e65-0dda-4fbb-8639-401772da7f90,
  abstract     = {{Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.}},
  author       = {{Lundwall, Åke and Lazure, C.}},
  issn         = {{1873-3468}},
  keywords     = {{*Prostatic Secretory Proteins; *Multigene Family; Molecular Sequence Data; Male; Humans; Guinea Pigs; Gonadal Steroid Hormones/genetics; *Exons; Molecular; *Evolution; Dna; Conserved Sequence; Animals; Base Sequence; Proteins/*genetics; Rats; Research Support; Non-U.S. Gov't; *Semen; Seminal Plasma Proteins; Seminal Vesicle Secretory Proteins; Sequence Homology; Nucleic Acid}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{6--53}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{FEBS Letters}},
  title        = {{A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon}},
  url          = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7589511}},
  volume       = {{374}},
  year         = {{1995}},
}