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Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?

Borrebaeck, Carl A K LU ; Malmborg, Ann-Christin LU and Ohlin, Mats LU orcid (1993) In Immunology Today 14(10). p.477-479
Abstract

Monoclonal antibodies have many potential therapeutic benefits. However, when applied to humans, mouse monoclonal antibodies have several disadvantages. Here Carl Borrebaeck and colleagues describe a strategy to overcome the anti-Gal activity, thought to be one of the reasons why mouse mAbs have a limited half-life.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Immunology Today
volume
14
issue
10
pages
3 pages
publisher
Elsevier
external identifiers
  • pmid:8274187
  • scopus:0027485672
ISSN
0167-5699
DOI
10.1016/0167-5699(93)90259-N
language
English
LU publication?
yes
id
39816fd2-df09-4b86-bc02-a4e8bda83eff
date added to LUP
2016-04-20 13:45:23
date last changed
2024-01-04 02:31:56
@article{39816fd2-df09-4b86-bc02-a4e8bda83eff,
  abstract     = {{<p>Monoclonal antibodies have many potential therapeutic benefits. However, when applied to humans, mouse monoclonal antibodies have several disadvantages. Here Carl Borrebaeck and colleagues describe a strategy to overcome the anti-Gal activity, thought to be one of the reasons why mouse mAbs have a limited half-life.</p>}},
  author       = {{Borrebaeck, Carl A K and Malmborg, Ann-Christin and Ohlin, Mats}},
  issn         = {{0167-5699}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{477--479}},
  publisher    = {{Elsevier}},
  series       = {{Immunology Today}},
  title        = {{Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?}},
  url          = {{http://dx.doi.org/10.1016/0167-5699(93)90259-N}},
  doi          = {{10.1016/0167-5699(93)90259-N}},
  volume       = {{14}},
  year         = {{1993}},
}