Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)
(2013) In Journal of Internal Medicine 274(1). p.52-66- Abstract
- Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods We conducted a randomized dietary study lasting for 18-24weeks in individuals with features of metabolic syndrome (mean age 55years, BMI 31.6kgm-2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables,... (More)
- Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods We conducted a randomized dietary study lasting for 18-24weeks in individuals with features of metabolic syndrome (mean age 55years, BMI 31.6kgm-2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. Results Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmolL-1 95% CI -0.35; -0.01, P=0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P=0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P=0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37ngL-1, P= 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P=0.049) and magnesium (mg, -0.23, -0.41; -0.05, P=0.012) were associated with IL-1 Ra. Conclusions Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation. (Less)
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https://lup.lub.lu.se/record/3987230
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiovascular risk, inflammation, intervention, metabolic syndrome, Nordic diet
- in
- Journal of Internal Medicine
- volume
- 274
- issue
- 1
- pages
- 52 - 66
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000320279000004
- scopus:84879123209
- pmid:23398528
- ISSN
- 1365-2796
- DOI
- 10.1111/joim.12044
- language
- English
- LU publication?
- yes
- id
- 14678e26-2019-413f-910e-37c558fb4f9b (old id 3987230)
- date added to LUP
- 2016-04-01 14:15:21
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- 2024-02-25 12:02:30
@article{14678e26-2019-413f-910e-37c558fb4f9b,
abstract = {{Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods We conducted a randomized dietary study lasting for 18-24weeks in individuals with features of metabolic syndrome (mean age 55years, BMI 31.6kgm-2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. Results Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmolL-1 95% CI -0.35; -0.01, P=0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P=0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P=0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37ngL-1, P= 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P=0.049) and magnesium (mg, -0.23, -0.41; -0.05, P=0.012) were associated with IL-1 Ra. Conclusions Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.}},
author = {{Uusitupa, M. and Hermansen, K. and Savolainen, M. J. and Schwab, U. and Kolehmainen, M. and Brader, L. and Mortensen, L. S. and Cloetens, Lieselotte and Johansson Persson, Anna and Önning, Gunilla and Landin-Olsson, Mona and Herzig, K. -H. and Hukkanen, J. and Rosqvist, F. and Iggman, D. and Paananen, J. and Pulkki, K. J. and Siloaho, M. and Dragsted, L. and Barri, T. and Overvad, K. and Knudsen, K. E. Bach and Hedemann, M. S. and Arner, P. and Dahlman, I. and Borge, G. I. A. and Baardseth, P. and Ulven, S. M. and Gunnarsdottir, I. and Jonsdottir, S. and Thorsdottir, I. and Oresic, M. and Poutanen, K. S. and Riserus, U. and Åkesson, Björn}},
issn = {{1365-2796}},
keywords = {{cardiovascular risk; inflammation; intervention; metabolic syndrome; Nordic diet}},
language = {{eng}},
number = {{1}},
pages = {{52--66}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)}},
url = {{http://dx.doi.org/10.1111/joim.12044}},
doi = {{10.1111/joim.12044}},
volume = {{274}},
year = {{2013}},
}