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SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening

Emdin, Stefan O. ; Granstrand, Bengt ; Ringberg, Anita LU ; Sandelin, Kerstin ; Arnesson, Lars-Gunnar ; Nordgren, Hans ; Anderson, Harald LU ; Garmo, Hans ; Holmberg, Lars and Wallgren, Arne (2006) In Acta Oncologica 45(5). p.536-543
Abstract
We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contralateral breast cancer, distant metastasis and death. After a median follow-up of 5.2 years (range 0.1-13.8) there were 44 recurrences in the RT group corresponding to a cumulative incidence of 0.07 (95% confidence interval (CI) 0.05-0.10). In the control group there were 117 recurrences giving a cumulative incidence of 0.22 (95% CI 0.18-0.26) giving... (More)
We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contralateral breast cancer, distant metastasis and death. After a median follow-up of 5.2 years (range 0.1-13.8) there were 44 recurrences in the RT group corresponding to a cumulative incidence of 0.07 (95% confidence interval (CI) 0.05-0.10). In the control group there were 117 recurrences giving a cumulative incidence of 0.22 (95% CI 0.18-0.26) giving an overall hazard ratio of 0.33 (95% CI 0.24-0.47, p < 0.0001). Twenty two percent of the patients had microscopically unknown or involved margins. We found no evidence for different effects of RT on the relative risk of invasive or in situ recurrence. Secondary endpoints did not differ. Women undergoing sector resection for DCIS under conditions of population based screening mammography benefit from postoperative RT to the breast. Seven patients needed RT-treatment to prevent one recurrence. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
45
issue
5
pages
536 - 543
publisher
Taylor & Francis
external identifiers
  • wos:000239275900004
  • scopus:33746772725
ISSN
1651-226X
DOI
10.1080/02841860600681569
language
English
LU publication?
yes
id
9e946acc-b72a-4729-abfc-ace6541234b6 (old id 399667)
date added to LUP
2016-04-01 16:36:00
date last changed
2022-02-20 07:05:37
@article{9e946acc-b72a-4729-abfc-ace6541234b6,
  abstract     = {{We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contralateral breast cancer, distant metastasis and death. After a median follow-up of 5.2 years (range 0.1-13.8) there were 44 recurrences in the RT group corresponding to a cumulative incidence of 0.07 (95% confidence interval (CI) 0.05-0.10). In the control group there were 117 recurrences giving a cumulative incidence of 0.22 (95% CI 0.18-0.26) giving an overall hazard ratio of 0.33 (95% CI 0.24-0.47, p &lt; 0.0001). Twenty two percent of the patients had microscopically unknown or involved margins. We found no evidence for different effects of RT on the relative risk of invasive or in situ recurrence. Secondary endpoints did not differ. Women undergoing sector resection for DCIS under conditions of population based screening mammography benefit from postoperative RT to the breast. Seven patients needed RT-treatment to prevent one recurrence.}},
  author       = {{Emdin, Stefan O. and Granstrand, Bengt and Ringberg, Anita and Sandelin, Kerstin and Arnesson, Lars-Gunnar and Nordgren, Hans and Anderson, Harald and Garmo, Hans and Holmberg, Lars and Wallgren, Arne}},
  issn         = {{1651-226X}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{536--543}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Oncologica}},
  title        = {{SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening}},
  url          = {{http://dx.doi.org/10.1080/02841860600681569}},
  doi          = {{10.1080/02841860600681569}},
  volume       = {{45}},
  year         = {{2006}},
}