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A pharmacoeconomic analysis of sertindole in the treatment of schizophrenia in Sweden

Lindström, Eva LU ; Eberhard, Jonas LU ; Fors, Björn M ; Hansen, Karina and Sapin, Christophe (2011) In Nordic Journal of Psychiatry 65(6). p.13-403
Abstract

BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.

AIM: A model was developed to compare the cost-effectiveness of a 5-year treatment strategy starting with sertindole versus olanzapine, risperidone, aripiprazole or the typical antipsychotic agent, haloperidol.

METHODS: The model was based on published trials and local clinical practice, and considered costs from the perspective of the Swedish National Health... (More)

BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.

AIM: A model was developed to compare the cost-effectiveness of a 5-year treatment strategy starting with sertindole versus olanzapine, risperidone, aripiprazole or the typical antipsychotic agent, haloperidol.

METHODS: The model was based on published trials and local clinical practice, and considered costs from the perspective of the Swedish National Health Insurance Board.

RESULTS: All atypical agents were clinically superior and more cost-effective than haloperidol with a cost per quality-adjusted life year gained of approximately 490,000 Swedish kroner. Sertindole was associated with the lowest direct and indirect medical costs, driven by its tolerability profile.

CONCLUSIONS: Sertindole represents a useful alternative to the current treatment options available in Sweden.

CLINICAL IMPLICATIONS: The relatively good tolerability profile of sertindole translates into lower costs of schizophrenia management, primarily driven by substantially lower direct and indirect costs. Sertindole appears to be a clinically and cost-effective alternative in the management of patients with schizophrenia in Sweden.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Antipsychotic Agents, Aripiprazole, Benzodiazepines, Cost-Benefit Analysis, Economics, Pharmaceutical, Female, Haloperidol, Humans, Imidazoles, Indoles, Male, Models, Economic, National Health Programs, Piperazines, Quinolones, Risperidone, Schizophrenia, Sweden
in
Nordic Journal of Psychiatry
volume
65
issue
6
pages
11 pages
publisher
Informa Healthcare
external identifiers
  • pmid:21770821
  • scopus:80055097521
ISSN
1502-4725
DOI
10.3109/08039488.2011.590603
language
English
LU publication?
no
id
3aef0e35-2ff5-49fd-839f-e5896d6a2be7
date added to LUP
2016-06-22 16:08:22
date last changed
2024-01-04 08:46:22
@article{3aef0e35-2ff5-49fd-839f-e5896d6a2be7,
  abstract     = {{<p>BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.</p><p>AIM: A model was developed to compare the cost-effectiveness of a 5-year treatment strategy starting with sertindole versus olanzapine, risperidone, aripiprazole or the typical antipsychotic agent, haloperidol.</p><p>METHODS: The model was based on published trials and local clinical practice, and considered costs from the perspective of the Swedish National Health Insurance Board.</p><p>RESULTS: All atypical agents were clinically superior and more cost-effective than haloperidol with a cost per quality-adjusted life year gained of approximately 490,000 Swedish kroner. Sertindole was associated with the lowest direct and indirect medical costs, driven by its tolerability profile.</p><p>CONCLUSIONS: Sertindole represents a useful alternative to the current treatment options available in Sweden.</p><p>CLINICAL IMPLICATIONS: The relatively good tolerability profile of sertindole translates into lower costs of schizophrenia management, primarily driven by substantially lower direct and indirect costs. Sertindole appears to be a clinically and cost-effective alternative in the management of patients with schizophrenia in Sweden.</p>}},
  author       = {{Lindström, Eva and Eberhard, Jonas and Fors, Björn M and Hansen, Karina and Sapin, Christophe}},
  issn         = {{1502-4725}},
  keywords     = {{Adult; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Cost-Benefit Analysis; Economics, Pharmaceutical; Female; Haloperidol; Humans; Imidazoles; Indoles; Male; Models, Economic; National Health Programs; Piperazines; Quinolones; Risperidone; Schizophrenia; Sweden}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{13--403}},
  publisher    = {{Informa Healthcare}},
  series       = {{Nordic Journal of Psychiatry}},
  title        = {{A pharmacoeconomic analysis of sertindole in the treatment of schizophrenia in Sweden}},
  url          = {{http://dx.doi.org/10.3109/08039488.2011.590603}},
  doi          = {{10.3109/08039488.2011.590603}},
  volume       = {{65}},
  year         = {{2011}},
}