Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patients with inactive systemic lupus erythematosus.

Tydén, Helena LU ; Lood, Christian LU ; Gullstrand, Birgitta LU ; Jönsen, Andreas LU ; Nived, Ola LU ; Sturfelt, Gunnar LU ; Truedsson, Lennart LU ; Ivars, Fredrik LU ; Leanderson, Tomas LU and Bengtsson, Anders LU (2013) In Rheumatology 52(11). p.2048-2055
Abstract
Objectives. Patients with SLE have an increased morbidity and mortality from cardiovascular disease (CVD). The reason for this is not entirely understood, but is believed to be partly related to the long-lasting inflammatory process seen in SLE. The aim of the present study was to investigate whether there is an association between CVD and serum levels of the proinflammatory proteins S100A8/A9 and S100A12 in SLE.Methods. Serum levels of S100A8/A9 and S100A12 were measured with ELISA in 237 SLE patients with clinically inactive disease and without infections, as well as in 100 healthy individuals. Cardiovascular manifestations were defined according to the SLICC/ACR Damage Index (SLICC/ACR-DI).Results. Serum levels of S100A8/A9 were... (More)
Objectives. Patients with SLE have an increased morbidity and mortality from cardiovascular disease (CVD). The reason for this is not entirely understood, but is believed to be partly related to the long-lasting inflammatory process seen in SLE. The aim of the present study was to investigate whether there is an association between CVD and serum levels of the proinflammatory proteins S100A8/A9 and S100A12 in SLE.Methods. Serum levels of S100A8/A9 and S100A12 were measured with ELISA in 237 SLE patients with clinically inactive disease and without infections, as well as in 100 healthy individuals. Cardiovascular manifestations were defined according to the SLICC/ACR Damage Index (SLICC/ACR-DI).Results. Serum levels of S100A8/A9 were elevated in our inactive SLE patients as compared with healthy individuals (P < 0.0001), which was not seen for S100A12 (P = 0.12). SLE patients with a history of CVD had increased serum levels of both S100A8/A9 and S100A12 compared with patients with no CVD or venous thromboembolism (P = 0.003 and P = 0.006, respectively). The presence of organ damage according to SLICC/ACR-DI was associated with an increase in both S100A8/A9 and S100A12 serum levels (P = 0.001 and P = 0.006, respectively).Conclusion. Elevated serum levels of S100A8/A9 and S100A12 may be used as an indicator of severe disease and CVD in SLE, suggesting that SLE patients with elevated serum S100A8/A9 and S100A12 concentrations may benefit from more intense cardiovascular primary preventive strategies and possibly also from more intense and early immunosuppressive treatment. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology
volume
52
issue
11
pages
2048 - 2055
publisher
Oxford University Press
external identifiers
  • wos:000325998000018
  • pmid:23942785
  • scopus:84886313953
ISSN
1462-0332
DOI
10.1093/rheumatology/ket263
language
English
LU publication?
yes
id
077224cf-1b83-4ff1-acc4-a299d3be0d50 (old id 4005734)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23942785?dopt=Abstract
date added to LUP
2016-04-01 11:11:29
date last changed
2022-04-28 08:00:55
@article{077224cf-1b83-4ff1-acc4-a299d3be0d50,
  abstract     = {{Objectives. Patients with SLE have an increased morbidity and mortality from cardiovascular disease (CVD). The reason for this is not entirely understood, but is believed to be partly related to the long-lasting inflammatory process seen in SLE. The aim of the present study was to investigate whether there is an association between CVD and serum levels of the proinflammatory proteins S100A8/A9 and S100A12 in SLE.Methods. Serum levels of S100A8/A9 and S100A12 were measured with ELISA in 237 SLE patients with clinically inactive disease and without infections, as well as in 100 healthy individuals. Cardiovascular manifestations were defined according to the SLICC/ACR Damage Index (SLICC/ACR-DI).Results. Serum levels of S100A8/A9 were elevated in our inactive SLE patients as compared with healthy individuals (P &lt; 0.0001), which was not seen for S100A12 (P = 0.12). SLE patients with a history of CVD had increased serum levels of both S100A8/A9 and S100A12 compared with patients with no CVD or venous thromboembolism (P = 0.003 and P = 0.006, respectively). The presence of organ damage according to SLICC/ACR-DI was associated with an increase in both S100A8/A9 and S100A12 serum levels (P = 0.001 and P = 0.006, respectively).Conclusion. Elevated serum levels of S100A8/A9 and S100A12 may be used as an indicator of severe disease and CVD in SLE, suggesting that SLE patients with elevated serum S100A8/A9 and S100A12 concentrations may benefit from more intense cardiovascular primary preventive strategies and possibly also from more intense and early immunosuppressive treatment.}},
  author       = {{Tydén, Helena and Lood, Christian and Gullstrand, Birgitta and Jönsen, Andreas and Nived, Ola and Sturfelt, Gunnar and Truedsson, Lennart and Ivars, Fredrik and Leanderson, Tomas and Bengtsson, Anders}},
  issn         = {{1462-0332}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2048--2055}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology}},
  title        = {{Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patients with inactive systemic lupus erythematosus.}},
  url          = {{http://dx.doi.org/10.1093/rheumatology/ket263}},
  doi          = {{10.1093/rheumatology/ket263}},
  volume       = {{52}},
  year         = {{2013}},
}