Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

On the complementarity of methods in structural biology

Liljas, Anders LU (2006) In Acta Crystallographica. Section D: Biological Crystallography 62(8). p.941-945
Abstract
Structural biology has transformed a number of fields of biochemistry and biology. A few examples are the following. The allosteric uptake and release of oxygen from haemoglobin obtained an elegant description from the work of Perutz [ Perutz ( 1970), Nature ( London), 227, 726 - 739; Perutz et al. ( 1998), Annu. Rev. Biophys. Biomol. Struct. 27, 1 - 34]. The structure of tRNA highlighted the fact that the two functional facets of the molecule, the anticodon and the 30- end, which is charged with amino acids, were 75 A apart [ Robertus et al. ( 1974), Nature ( London), 250, 546 - 551; Kim et al. ( 1974), Science, 185, 435 - 440]. This had interesting consequences both for charging by tRNA synthetases and for the role of tRNA as the adaptor... (More)
Structural biology has transformed a number of fields of biochemistry and biology. A few examples are the following. The allosteric uptake and release of oxygen from haemoglobin obtained an elegant description from the work of Perutz [ Perutz ( 1970), Nature ( London), 227, 726 - 739; Perutz et al. ( 1998), Annu. Rev. Biophys. Biomol. Struct. 27, 1 - 34]. The structure of tRNA highlighted the fact that the two functional facets of the molecule, the anticodon and the 30- end, which is charged with amino acids, were 75 A apart [ Robertus et al. ( 1974), Nature ( London), 250, 546 - 551; Kim et al. ( 1974), Science, 185, 435 - 440]. This had interesting consequences both for charging by tRNA synthetases and for the role of tRNA as the adaptor in protein synthesis on the ribosome. The structure of the ATP synthase illustrated how the enzyme could hydrolyze or synthesize ATP by a rotating mechanism [ Abrahams et al. ( 1994), Nature ( London), 370, 621 - 628]. This transformation is a consequence of the fact that such structural insights on different levels and of different characters can provide a basis for the interpretation or reinterpretation of old observations. In addition, the design of experiments from a structural basis has become more relevant and focused. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Crystallographica. Section D: Biological Crystallography
volume
62
issue
8
pages
941 - 945
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000239119800014
  • pmid:16855312
  • scopus:33746468646
ISSN
1399-0047
DOI
10.1107/S0907444906008900
language
English
LU publication?
yes
id
e8a7fcc9-9e96-4aa1-a711-a116974a7d3e (old id 401470)
date added to LUP
2016-04-01 15:39:57
date last changed
2022-01-28 06:27:34
@article{e8a7fcc9-9e96-4aa1-a711-a116974a7d3e,
  abstract     = {{Structural biology has transformed a number of fields of biochemistry and biology. A few examples are the following. The allosteric uptake and release of oxygen from haemoglobin obtained an elegant description from the work of Perutz [ Perutz ( 1970), Nature ( London), 227, 726 - 739; Perutz et al. ( 1998), Annu. Rev. Biophys. Biomol. Struct. 27, 1 - 34]. The structure of tRNA highlighted the fact that the two functional facets of the molecule, the anticodon and the 30- end, which is charged with amino acids, were 75 A apart [ Robertus et al. ( 1974), Nature ( London), 250, 546 - 551; Kim et al. ( 1974), Science, 185, 435 - 440]. This had interesting consequences both for charging by tRNA synthetases and for the role of tRNA as the adaptor in protein synthesis on the ribosome. The structure of the ATP synthase illustrated how the enzyme could hydrolyze or synthesize ATP by a rotating mechanism [ Abrahams et al. ( 1994), Nature ( London), 370, 621 - 628]. This transformation is a consequence of the fact that such structural insights on different levels and of different characters can provide a basis for the interpretation or reinterpretation of old observations. In addition, the design of experiments from a structural basis has become more relevant and focused.}},
  author       = {{Liljas, Anders}},
  issn         = {{1399-0047}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{941--945}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Acta Crystallographica. Section D: Biological Crystallography}},
  title        = {{On the complementarity of methods in structural biology}},
  url          = {{http://dx.doi.org/10.1107/S0907444906008900}},
  doi          = {{10.1107/S0907444906008900}},
  volume       = {{62}},
  year         = {{2006}},
}