Challenges in estimating the validity of dietary acrylamide measurements
(2013) In European Journal of Nutrition 52(5). p.1503-1512- Abstract
- Acrylamide is a chemical compound present in tobacco smoke and food, classified as a probable human carcinogen and a known human neurotoxin. Acrylamide is formed in foods, typically carbohydrate-rich and protein-poor plant foods, during high-temperature cooking or other thermal processing. The objectives of this study were to compare dietary estimates of acrylamide from questionnaires (DQ) and 24-h recalls (R) with levels of acrylamide adduct (AA) in haemoglobin. In the European Prospective Investigation into Cancer and Nutrition (EPIC) study, acrylamide exposure was assessed in 510 participants from 9 European countries, randomly selected and stratified by age, sex, with equal numbers of never and current smokers. After adjusting for... (More)
- Acrylamide is a chemical compound present in tobacco smoke and food, classified as a probable human carcinogen and a known human neurotoxin. Acrylamide is formed in foods, typically carbohydrate-rich and protein-poor plant foods, during high-temperature cooking or other thermal processing. The objectives of this study were to compare dietary estimates of acrylamide from questionnaires (DQ) and 24-h recalls (R) with levels of acrylamide adduct (AA) in haemoglobin. In the European Prospective Investigation into Cancer and Nutrition (EPIC) study, acrylamide exposure was assessed in 510 participants from 9 European countries, randomly selected and stratified by age, sex, with equal numbers of never and current smokers. After adjusting for country, alcohol intake, smoking status, number of cigarettes and energy intake, correlation coefficients between various acrylamide measurements were computed, both at the individual and at the aggregate (centre) level. Individual level correlation coefficient between DQ and R measurements (r (DQ,R)) was 0.17, while r (DQ,AA) and r (R,AA) were 0.08 and 0.06, respectively. In never smokers, r (DQ,R), r (DQ,AA) and r (R,AA) were 0.19, 0.09 and 0.02, respectively. The correlation coefficients between means of DQ, R and AA measurements at the centre level were larger (r > 0.4). These findings suggest that estimates of total acrylamide intake based on self-reported diet correlate weakly with biomarker AA Hb levels. Possible explanations are the lack of AA levels to capture dietary acrylamide due to individual differences in the absorption and metabolism of acrylamide, and/or measurement errors in acrylamide from self-reported dietary assessments, thus limiting the possibility to validate acrylamide DQ measurements. (Less)
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https://lup.lub.lu.se/record/4050289
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acrylamide, Dietary questionnaires, Haemoglobin adducts, Biomarkers, Smoking, Measurement errors
- in
- European Journal of Nutrition
- volume
- 52
- issue
- 5
- pages
- 1503 - 1512
- publisher
- Springer
- external identifiers
-
- wos:000322008000008
- scopus:84880767724
- pmid:23114503
- ISSN
- 1436-6215
- DOI
- 10.1007/s00394-012-0457-7
- language
- English
- LU publication?
- yes
- id
- f99afb76-5015-494d-ac7e-e5e1937bc2e1 (old id 4050289)
- date added to LUP
- 2016-04-01 10:17:37
- date last changed
- 2022-03-04 18:12:42
@article{f99afb76-5015-494d-ac7e-e5e1937bc2e1,
abstract = {{Acrylamide is a chemical compound present in tobacco smoke and food, classified as a probable human carcinogen and a known human neurotoxin. Acrylamide is formed in foods, typically carbohydrate-rich and protein-poor plant foods, during high-temperature cooking or other thermal processing. The objectives of this study were to compare dietary estimates of acrylamide from questionnaires (DQ) and 24-h recalls (R) with levels of acrylamide adduct (AA) in haemoglobin. In the European Prospective Investigation into Cancer and Nutrition (EPIC) study, acrylamide exposure was assessed in 510 participants from 9 European countries, randomly selected and stratified by age, sex, with equal numbers of never and current smokers. After adjusting for country, alcohol intake, smoking status, number of cigarettes and energy intake, correlation coefficients between various acrylamide measurements were computed, both at the individual and at the aggregate (centre) level. Individual level correlation coefficient between DQ and R measurements (r (DQ,R)) was 0.17, while r (DQ,AA) and r (R,AA) were 0.08 and 0.06, respectively. In never smokers, r (DQ,R), r (DQ,AA) and r (R,AA) were 0.19, 0.09 and 0.02, respectively. The correlation coefficients between means of DQ, R and AA measurements at the centre level were larger (r > 0.4). These findings suggest that estimates of total acrylamide intake based on self-reported diet correlate weakly with biomarker AA Hb levels. Possible explanations are the lack of AA levels to capture dietary acrylamide due to individual differences in the absorption and metabolism of acrylamide, and/or measurement errors in acrylamide from self-reported dietary assessments, thus limiting the possibility to validate acrylamide DQ measurements.}},
author = {{Ferrari, Pietro and Freisling, Heinz and Duell, Eric J. and Kaaks, Rudolf and Lujan-Barroso, Leila and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Nailler, Laura and Polidoro, Silvia and Mattiello, Amalia and Palli, Domenico and Tumino, Rosario and Grioni, Sara and Knueppel, Sven and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Orfanos, Philippos and Katsoulis, Michail and Trichopoulou, Antonia and Ramon Quiros, Jose and Ardanaz, Eva and Maria Huerta, Jose and Amiano Etxezarreta, Pilar and Jose Sanchez, Maria and Crowe, Francesca and Khaw, Kay-Tee and Wareham, Nicholas J. and Ocke, Marga and Bueno-de-Mesquita, Bas and Peeters, Petra H. M. and Ericson, Ulrika and Wirfält, Elisabet and Hallmans, Goeran and Johansson, Ingegerd and Engeset, Dagrun and Nicolas, Genevieve and Gallo, Valentina and Norat, Teresa and Riboli, Elio and Slimani, Nadia}},
issn = {{1436-6215}},
keywords = {{Acrylamide; Dietary questionnaires; Haemoglobin adducts; Biomarkers; Smoking; Measurement errors}},
language = {{eng}},
number = {{5}},
pages = {{1503--1512}},
publisher = {{Springer}},
series = {{European Journal of Nutrition}},
title = {{Challenges in estimating the validity of dietary acrylamide measurements}},
url = {{http://dx.doi.org/10.1007/s00394-012-0457-7}},
doi = {{10.1007/s00394-012-0457-7}},
volume = {{52}},
year = {{2013}},
}