Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(2013) In Annals of Oncology 24(10). p.2645-2651- Abstract
- In 1994, acrylamide (AA) was classified as a probable human carcinogen by the International Agency for Research on Cancer. In 2002, AA was discovered at relatively high concentrations in some starchy, plant-based foods cooked at high temperatures. A prospective analysis was conducted to evaluate the association between the dietary intake of AA and ductal adenocarcinoma of the exocrine pancreatic cancer (PC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort using Cox regression modeling. EPIC includes > 500 000 men and women aged 35-75 at enrollment from 10 European countries. AA intake was estimated for each participant by combining questionnaire-based food consumption data with a harmonized AA... (More)
- In 1994, acrylamide (AA) was classified as a probable human carcinogen by the International Agency for Research on Cancer. In 2002, AA was discovered at relatively high concentrations in some starchy, plant-based foods cooked at high temperatures. A prospective analysis was conducted to evaluate the association between the dietary intake of AA and ductal adenocarcinoma of the exocrine pancreatic cancer (PC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort using Cox regression modeling. EPIC includes > 500 000 men and women aged 35-75 at enrollment from 10 European countries. AA intake was estimated for each participant by combining questionnaire-based food consumption data with a harmonized AA database derived from the EU monitoring database of AA levels in foods, and evaluated in quintiles and continuously. After a mean follow-up of 11 years, 865 first incident adenocarcinomas of the exocrine pancreas were observed and included in the present analysis. At baseline, the mean dietary AA intake in EPIC was 26.22 mu g/day. No overall association was found between continuous or quintiles of dietary AA intake and PC risk in EPIC (HR:0.95, 95%CI:0.89-1.01 per 10 mu g/day). There was no effect measure modification by smoking status, sex, diabetes, alcohol intake or geographic region. However, there was an inverse association (HR: 0.73, 95% CI: 0.61-0.88 per 10 mu g/day) between AA intake and PC risk in obese persons as defined using the body mass index (BMI, >= 30 kg/m(2)), but not when body fatness was defined using waist and hip circumference or their ratio. Dietary intake of AA was not associated with an increased risk of PC in the EPIC cohort. (Less)
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- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acrylamide, cohort, nutrition, pancreatic cancer
- in
- Annals of Oncology
- volume
- 24
- issue
- 10
- pages
- 2645 - 2651
- publisher
- Oxford University Press
- external identifiers
-
- wos:000325153800031
- scopus:84884708687
- pmid:23857962
- ISSN
- 1569-8041
- DOI
- 10.1093/annonc/mdt255
- language
- English
- LU publication?
- yes
- id
- 736f475d-14c6-49d0-95ee-6b0ba7007162 (old id 4171913)
- date added to LUP
- 2016-04-01 14:30:00
- date last changed
- 2022-04-11 12:31:39
@article{736f475d-14c6-49d0-95ee-6b0ba7007162,
abstract = {{In 1994, acrylamide (AA) was classified as a probable human carcinogen by the International Agency for Research on Cancer. In 2002, AA was discovered at relatively high concentrations in some starchy, plant-based foods cooked at high temperatures. A prospective analysis was conducted to evaluate the association between the dietary intake of AA and ductal adenocarcinoma of the exocrine pancreatic cancer (PC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort using Cox regression modeling. EPIC includes > 500 000 men and women aged 35-75 at enrollment from 10 European countries. AA intake was estimated for each participant by combining questionnaire-based food consumption data with a harmonized AA database derived from the EU monitoring database of AA levels in foods, and evaluated in quintiles and continuously. After a mean follow-up of 11 years, 865 first incident adenocarcinomas of the exocrine pancreas were observed and included in the present analysis. At baseline, the mean dietary AA intake in EPIC was 26.22 mu g/day. No overall association was found between continuous or quintiles of dietary AA intake and PC risk in EPIC (HR:0.95, 95%CI:0.89-1.01 per 10 mu g/day). There was no effect measure modification by smoking status, sex, diabetes, alcohol intake or geographic region. However, there was an inverse association (HR: 0.73, 95% CI: 0.61-0.88 per 10 mu g/day) between AA intake and PC risk in obese persons as defined using the body mass index (BMI, >= 30 kg/m(2)), but not when body fatness was defined using waist and hip circumference or their ratio. Dietary intake of AA was not associated with an increased risk of PC in the EPIC cohort.}},
author = {{Obon-Santacana, M. and Slimani, N. and Lujan-Barroso, L. and Travier, N. and Hallmans, G. and Freisling, H. and Ferrari, P. and Boutron-Ruault, M. C. and Racine, A. and Clavel, F. and Saieva, C. and Pala, V. and Tumino, R. and Mattiello, A. and Vineis, P. and Argueelles, M. and Ardanaz, E. and Amiano, P. and Navarro, C. and Sanchez, M. J. and Montes, E. Molina and Key, T. and Khaw, K. -T. and Wareham, N. and Peeters, P. H. and Trichopoulou, A. and Bamia, C. and Trichopoulos, D. and Boeing, H. and Kaaks, R. and Katzke, V. and Ye, W. and Sund, M. and Ericson, Ulrika and Wirfält, Elisabet and Overvad, K. and Tjonneland, A. and Olsen, A. and Skeie, G. and Asli, L. A. and Weiderpass, E. and Riboli, E. and Bueno-De-Mesquita, H. B. and Duell, E. J.}},
issn = {{1569-8041}},
keywords = {{acrylamide; cohort; nutrition; pancreatic cancer}},
language = {{eng}},
number = {{10}},
pages = {{2645--2651}},
publisher = {{Oxford University Press}},
series = {{Annals of Oncology}},
title = {{Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort}},
url = {{http://dx.doi.org/10.1093/annonc/mdt255}},
doi = {{10.1093/annonc/mdt255}},
volume = {{24}},
year = {{2013}},
}