Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study.
Lundin, Patrik ; Krite Svanberg, Emilie LU ; Cocola, Lorenzo ; Xu, Märta Lewander ; Somesfalean, Gabriel ; Andersson-Engels, Stefan ; Jahr, John LU ; Fellman, Vineta LU
; Svanberg, Katarina
LU
and Svanberg, Sune
(2013)
In Journal of Biomedical Optics
18(12).
- Abstract
- ABSTRACT. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and... (More)
- ABSTRACT. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and detecting light a few centimeters away. Water vapor was easily detected in the intestines and was also observed in the lungs. The relatively thick chest walls of the infants prevented detection of the weaker oxygen signal in this study. However, results from a previous phantom study, together with scaling of the results presented here to the typical chest-wall thickness of preterm infants, suggest that oxygen also should be detectable in their lungs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4223147
- author
- Lundin, Patrik
; Krite Svanberg, Emilie
LU
; Cocola, Lorenzo
; Xu, Märta Lewander
; Somesfalean, Gabriel
; Andersson-Engels, Stefan
; Jahr, John
LU
; Fellman, Vineta
LU
; Svanberg, Katarina
LU
and Svanberg, Sune
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biomedical Optics
- volume
- 18
- issue
- 12
- article number
- 127005
- publisher
- SPIE
- external identifiers
-
- pmid:24362929
- wos:000331706500046
- scopus:84890927050
- pmid:24362929
- ISSN
- 1083-3668
- DOI
- 10.1117/1.JBO.18.12.127005
- language
- English
- LU publication?
- yes
- id
- 51b5efee-9a74-47e1-a2cd-8f95e3664797 (old id 4223147)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24362929?dopt=Abstract
- date added to LUP
- 2016-04-01 10:15:18
- date last changed
- 2022-04-27 20:16:53
@article{51b5efee-9a74-47e1-a2cd-8f95e3664797,
abstract = {{ABSTRACT. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and detecting light a few centimeters away. Water vapor was easily detected in the intestines and was also observed in the lungs. The relatively thick chest walls of the infants prevented detection of the weaker oxygen signal in this study. However, results from a previous phantom study, together with scaling of the results presented here to the typical chest-wall thickness of preterm infants, suggest that oxygen also should be detectable in their lungs.}},
author = {{Lundin, Patrik and Krite Svanberg, Emilie and Cocola, Lorenzo and Xu, Märta Lewander and Somesfalean, Gabriel and Andersson-Engels, Stefan and Jahr, John and Fellman, Vineta and Svanberg, Katarina and Svanberg, Sune}},
issn = {{1083-3668}},
language = {{eng}},
number = {{12}},
publisher = {{SPIE}},
series = {{Journal of Biomedical Optics}},
title = {{Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study.}},
url = {{http://dx.doi.org/10.1117/1.JBO.18.12.127005}},
doi = {{10.1117/1.JBO.18.12.127005}},
volume = {{18}},
year = {{2013}},
}