Clonal alteration of breast cancer receptors between primary ductal carcinoma in situ (DCIS) and corresponding local events
Karlsson, E. ; Sandelin, K. ; Appelgren, J. ; Zhou, W. ; Jirström, Karin LU
; Bergh, J.
and Warnberg, F.
(2014)
In European Journal of Cancer
50(3).
p.517-524
- Abstract
- Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcinoma in situ (DCIS) and intra-individually matched ipsilateral event. Materials and methods: The cohort includes 1504 patients, diagnosed with a primary DCIS between 1986 and 2004. Of the 274 patients who developed a local relapse, 135 developed a new in situ carcinoma and 139 an invasive cancer up to 31st December 2011. ER and PR were identified... (More)
- Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcinoma in situ (DCIS) and intra-individually matched ipsilateral event. Materials and methods: The cohort includes 1504 patients, diagnosed with a primary DCIS between 1986 and 2004. Of the 274 patients who developed a local relapse, 135 developed a new in situ carcinoma and 139 an invasive cancer up to 31st December 2011. ER and PR were identified by immunohistochemistry (IHC) and HER2 by silver-enhanced in situ hybridisation (SISH) as well as IHC. Results: ER (n = 112), PR (n = 113) and HER2 (n = 114) status from both the primary DCIS and the corresponding relapse were assessed and were demonstrated to be discordant in 15.1%, 29.2% and 10.5% respectively. The receptor conversion was both from negative to positive and from positive to negative with no general pattern being seen in spite of sub-dividing into in situ relapse and invasive relapse. However, primary DCIS was HER2 positive in 40.3% whereas in situ and invasive relapses were HER2 positive in 42.9% and 34.5% respectively. Conclusions: Receptor conversion for ER, PR and HER2 status occurred between primary DCIS and corresponding local relapse in 10-30%. This study could not confirm that HER2 overexpression in primary DCIS had any impact on tumour progression to invasive cancer which has been proposed. (C) 2013 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4318529
- author
- Karlsson, E.
; Sandelin, K.
; Appelgren, J.
; Zhou, W.
; Jirström, Karin
LU
; Bergh, J.
and Warnberg, F.
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ductal carcinoma in situ, DCIS, Breast cancer, Hormonal receptor, ER, Oestrogen receptor, PR, Progesterone receptor, Human epidermal growth, factor receptor 2, HER2
- in
- European Journal of Cancer
- volume
- 50
- issue
- 3
- pages
- 517 - 524
- publisher
- Elsevier
- external identifiers
-
- wos:000330184400006
- scopus:84893691711
- ISSN
- 1879-0852
- DOI
- 10.1016/j.ejca.2013.10.020
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 6e30f6cc-fb73-4e61-aa6f-b5b04bf32548 (old id 4318529)
- date added to LUP
- 2016-04-01 10:04:29
- date last changed
- 2024-01-06 06:55:21
@article{6e30f6cc-fb73-4e61-aa6f-b5b04bf32548,
abstract = {{Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcinoma in situ (DCIS) and intra-individually matched ipsilateral event. Materials and methods: The cohort includes 1504 patients, diagnosed with a primary DCIS between 1986 and 2004. Of the 274 patients who developed a local relapse, 135 developed a new in situ carcinoma and 139 an invasive cancer up to 31st December 2011. ER and PR were identified by immunohistochemistry (IHC) and HER2 by silver-enhanced in situ hybridisation (SISH) as well as IHC. Results: ER (n = 112), PR (n = 113) and HER2 (n = 114) status from both the primary DCIS and the corresponding relapse were assessed and were demonstrated to be discordant in 15.1%, 29.2% and 10.5% respectively. The receptor conversion was both from negative to positive and from positive to negative with no general pattern being seen in spite of sub-dividing into in situ relapse and invasive relapse. However, primary DCIS was HER2 positive in 40.3% whereas in situ and invasive relapses were HER2 positive in 42.9% and 34.5% respectively. Conclusions: Receptor conversion for ER, PR and HER2 status occurred between primary DCIS and corresponding local relapse in 10-30%. This study could not confirm that HER2 overexpression in primary DCIS had any impact on tumour progression to invasive cancer which has been proposed. (C) 2013 Elsevier Ltd. All rights reserved.}},
author = {{Karlsson, E. and Sandelin, K. and Appelgren, J. and Zhou, W. and Jirström, Karin and Bergh, J. and Warnberg, F.}},
issn = {{1879-0852}},
keywords = {{Ductal carcinoma in situ; DCIS; Breast cancer; Hormonal receptor; ER; Oestrogen receptor; PR; Progesterone receptor; Human epidermal growth; factor receptor 2; HER2}},
language = {{eng}},
number = {{3}},
pages = {{517--524}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{Clonal alteration of breast cancer receptors between primary ductal carcinoma in situ (DCIS) and corresponding local events}},
url = {{http://dx.doi.org/10.1016/j.ejca.2013.10.020}},
doi = {{10.1016/j.ejca.2013.10.020}},
volume = {{50}},
year = {{2014}},
}