Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The Target for Statins, HMG-CoA Reductase, Is Expressed in Ductal Carcinoma-In Situ and May Predict Patient Response to Radiotherapy.

Butt, Salma LU ; Butt, Talha LU ; Jirström, Karin LU orcid ; Werner Hartman, Linda LU ; Amini, Rose-Marie ; Zhou, Wenjing ; Wärnberg, Fredrik and Borgquist, Signe LU (2014) In Annals of Surgical Oncology 21(9). p.2911-2919
Abstract
Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway. The aim of this study was to examine HMGCR expression in DCIS and study its treatment predictive value.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Surgical Oncology
volume
21
issue
9
pages
2911 - 2919
publisher
Springer
external identifiers
  • pmid:24777857
  • wos:000342143100017
  • scopus:84906261489
  • pmid:24777857
ISSN
1534-4681
DOI
10.1245/s10434-014-3708-4
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cancer Epidemiology (013007100), Pathology, (Lund) (013030000), Oncology, MV (013035000), Surgery Research Unit (013242220)
id
6729697b-757d-43ce-9363-1f5df1d8dd9c (old id 4429338)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24777857?dopt=Abstract
date added to LUP
2016-04-01 10:53:39
date last changed
2024-01-07 03:49:58
@article{6729697b-757d-43ce-9363-1f5df1d8dd9c,
  abstract     = {{Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway. The aim of this study was to examine HMGCR expression in DCIS and study its treatment predictive value.}},
  author       = {{Butt, Salma and Butt, Talha and Jirström, Karin and Werner Hartman, Linda and Amini, Rose-Marie and Zhou, Wenjing and Wärnberg, Fredrik and Borgquist, Signe}},
  issn         = {{1534-4681}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2911--2919}},
  publisher    = {{Springer}},
  series       = {{Annals of Surgical Oncology}},
  title        = {{The Target for Statins, HMG-CoA Reductase, Is Expressed in Ductal Carcinoma-In Situ and May Predict Patient Response to Radiotherapy.}},
  url          = {{http://dx.doi.org/10.1245/s10434-014-3708-4}},
  doi          = {{10.1245/s10434-014-3708-4}},
  volume       = {{21}},
  year         = {{2014}},
}