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A Compartmental Model of Mouse Thrombopoiesis and Erythropoiesis to Predict Bone Marrow Toxicity After Internal Irradiation.

Sas, Nicolas ; Rousseau, Julie ; Nguyen, Frédérique ; Bellec, Elise ; Larsson, Erik LU ; Becavin, Sonia ; Hindorf, Cecilia LU ; Abadie, Jérôme ; Chouin, Nicolas and Barbet, Jacques (2014) In Journal of Nuclear Medicine 55(8). p.1355-1360
Abstract
In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with experimental toxicity for several stages of differentiation of the 2 hematopoietic lineages.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
55
issue
8
pages
1355 - 1360
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:24935991
  • wos:000340022300028
  • scopus:84905482215
  • pmid:24935991
ISSN
0161-5505
DOI
10.2967/jnumed.113.133330
language
English
LU publication?
yes
id
352acbe5-de30-4575-b3d0-b91f2d7b3558 (old id 4528363)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24935991?dopt=Abstract
date added to LUP
2016-04-01 10:34:58
date last changed
2022-01-26 00:39:27
@article{352acbe5-de30-4575-b3d0-b91f2d7b3558,
  abstract     = {{In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with experimental toxicity for several stages of differentiation of the 2 hematopoietic lineages.}},
  author       = {{Sas, Nicolas and Rousseau, Julie and Nguyen, Frédérique and Bellec, Elise and Larsson, Erik and Becavin, Sonia and Hindorf, Cecilia and Abadie, Jérôme and Chouin, Nicolas and Barbet, Jacques}},
  issn         = {{0161-5505}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1355--1360}},
  publisher    = {{Society of Nuclear Medicine}},
  series       = {{Journal of Nuclear Medicine}},
  title        = {{A Compartmental Model of Mouse Thrombopoiesis and Erythropoiesis to Predict Bone Marrow Toxicity After Internal Irradiation.}},
  url          = {{http://dx.doi.org/10.2967/jnumed.113.133330}},
  doi          = {{10.2967/jnumed.113.133330}},
  volume       = {{55}},
  year         = {{2014}},
}