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The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

Jakubowski, Joseph A ; Angiolillo, Dominick J ; Zhou, Chunmei ; Small, David S ; Moser, Brian A ; Ten Berg, Jurrien M ; Brown, Patricia B ; James, Stefan ; Winters, Kenneth J and Erlinge, David LU orcid (2014) In Thrombosis Research 134(3). p.552-557
Abstract
Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
134
issue
3
pages
552 - 557
publisher
Elsevier
external identifiers
  • pmid:25022828
  • wos:000341310000006
  • pmid:25022828
  • scopus:85027922782
ISSN
1879-2472
DOI
10.1016/j.thromres.2014.05.019
language
English
LU publication?
yes
id
27c8e49b-b3d7-4f33-9993-934e594d1e5d (old id 4582351)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25022828?dopt=Abstract
date added to LUP
2016-04-01 11:00:19
date last changed
2022-04-28 03:41:58
@article{27c8e49b-b3d7-4f33-9993-934e594d1e5d,
  abstract     = {{Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.}},
  author       = {{Jakubowski, Joseph A and Angiolillo, Dominick J and Zhou, Chunmei and Small, David S and Moser, Brian A and Ten Berg, Jurrien M and Brown, Patricia B and James, Stefan and Winters, Kenneth J and Erlinge, David}},
  issn         = {{1879-2472}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{552--557}},
  publisher    = {{Elsevier}},
  series       = {{Thrombosis Research}},
  title        = {{The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.}},
  url          = {{http://dx.doi.org/10.1016/j.thromres.2014.05.019}},
  doi          = {{10.1016/j.thromres.2014.05.019}},
  volume       = {{134}},
  year         = {{2014}},
}