Potential of multi-photon upconversion emissions for fluorescence diffuse optical imaging
(2014) In Optics Express 22(15). p.17782-17790- Abstract
- The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversion emissions from rare-earth-doped upconverting nanoparticles for the improvement in spatial resolution of diffuse optical imaging. It is found that the imaging resolution is increased by a factor of 1.45 through employing two-photon upconversion emission compared with using the linear emission, and can be further elevated by a factor of 1.23 by using three-photon upconversion emission. In addition, we demonstrate that the... (More)
- The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversion emissions from rare-earth-doped upconverting nanoparticles for the improvement in spatial resolution of diffuse optical imaging. It is found that the imaging resolution is increased by a factor of 1.45 through employing two-photon upconversion emission compared with using the linear emission, and can be further elevated by a factor of 1.23 by using three-photon upconversion emission. In addition, we demonstrate that the pulsed excitation approach holds the promise of overcoming the low quantum yield associated with the high-order upconversion emissions. (C) 2014 Optical Society of America (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4655936
- author
- Liu, Haichun LU ; Xu, Can LU and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Optics Express
- volume
- 22
- issue
- 15
- pages
- 17782 - 17790
- publisher
- Optical Society of America
- external identifiers
-
- wos:000340685600020
- scopus:84905374484
- ISSN
- 1094-4087
- DOI
- 10.1364/OE.22.017782
- language
- English
- LU publication?
- yes
- id
- 244478a9-7464-4723-84b2-784538048e17 (old id 4655936)
- date added to LUP
- 2016-04-01 15:04:40
- date last changed
- 2022-01-28 03:59:42
@article{244478a9-7464-4723-84b2-784538048e17,
abstract = {{The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversion emissions from rare-earth-doped upconverting nanoparticles for the improvement in spatial resolution of diffuse optical imaging. It is found that the imaging resolution is increased by a factor of 1.45 through employing two-photon upconversion emission compared with using the linear emission, and can be further elevated by a factor of 1.23 by using three-photon upconversion emission. In addition, we demonstrate that the pulsed excitation approach holds the promise of overcoming the low quantum yield associated with the high-order upconversion emissions. (C) 2014 Optical Society of America}},
author = {{Liu, Haichun and Xu, Can and Andersson-Engels, Stefan}},
issn = {{1094-4087}},
language = {{eng}},
number = {{15}},
pages = {{17782--17790}},
publisher = {{Optical Society of America}},
series = {{Optics Express}},
title = {{Potential of multi-photon upconversion emissions for fluorescence diffuse optical imaging}},
url = {{http://dx.doi.org/10.1364/OE.22.017782}},
doi = {{10.1364/OE.22.017782}},
volume = {{22}},
year = {{2014}},
}