Beta Camera: Development and applications.
(2003)- Abstract
- A new detector for on-line digital detection of charged particles (beta-particles, conversion electrons and alpha-particles) from thin samples for rapid autoradiography has been developed; the Beta Camera. The device consists of a photon-sensitive detector (image photon detector, IPD); the main component of which is a microchannel plate. The sample to be measured is mounted in close contact to a thin scintillator on the IPD. Electrons are generated from the photocathode and the electron avalanche through the microchannel plate is registered by a resistive anode. The results are stored in an image memory for visual studies and further processing.
The detector has a linear response making quantification easy. Results show... (More) - A new detector for on-line digital detection of charged particles (beta-particles, conversion electrons and alpha-particles) from thin samples for rapid autoradiography has been developed; the Beta Camera. The device consists of a photon-sensitive detector (image photon detector, IPD); the main component of which is a microchannel plate. The sample to be measured is mounted in close contact to a thin scintillator on the IPD. Electrons are generated from the photocathode and the electron avalanche through the microchannel plate is registered by a resistive anode. The results are stored in an image memory for visual studies and further processing.
The detector has a linear response making quantification easy. Results show that the Beta Camera can image radionuclide distributions with a spatial resolution of 500 µm, has good homogeneity and time resolution, and better sensitivy than film autoradiography. Biomedical samples have been imaged with the Beta Camera in several applications in real time.
The open face of the detector (the scintillator) gives considerable freedom allowing a wide range of applications. In this thesis various examples of the use of the Beta Camera are given, such as imaging of tumours, normal tissues and living cells (nerves), as well as alpha-emitting environmental samples.
The Beta Camera developed in this work has shown to provide a complement to ordinary filmautoradiography, but with fast, real-time and digital registration of radionuclide distributions. (Less) - Abstract (Swedish)
- Popular Abstract in Swedish
En ny bildgivande detektor för realtids registreringar av laddade partiklar (beta-partiklar, konversions-elektroner och alfa-partiklar) från tunna preparat har utvecklats, Betakamera. Den består av en ljuskänslig detektor, baserad på mikrokanalplattor, en fotokatod och en resistiv anod . Preparatet som ska registreras placeras mot en plastscintillator, vilken är monterad på den ljuskänsliga detektorn. Då en laddad partikel träffar scintillatorn genereras scintillationsljus som via ett optisk fönster når katoden. Ljuset konverteras till fotoelektroner, som accelereras och via kanalplattorna generas en kaskad av elektroner som träffar den resistiva anoden. Anoden erhåller en laddning som är... (More) - Popular Abstract in Swedish
En ny bildgivande detektor för realtids registreringar av laddade partiklar (beta-partiklar, konversions-elektroner och alfa-partiklar) från tunna preparat har utvecklats, Betakamera. Den består av en ljuskänslig detektor, baserad på mikrokanalplattor, en fotokatod och en resistiv anod . Preparatet som ska registreras placeras mot en plastscintillator, vilken är monterad på den ljuskänsliga detektorn. Då en laddad partikel träffar scintillatorn genereras scintillationsljus som via ett optisk fönster når katoden. Ljuset konverteras till fotoelektroner, som accelereras och via kanalplattorna generas en kaskad av elektroner som träffar den resistiva anoden. Anoden erhåller en laddning som är proportionell mot den laddade partikelns energi. Denna laddning från anoden delas upp till positionssignaler som digitaliseras och lagras i ett bildminne för visuell bedömning eller vidare bildbehandling.
Detektorn är linjär, vilket innebär att det är lätt att kvantifiera. Resultat visar att Betakameran kan registrera radionuklidfördelningar med en spatiell upplösning av 500 µm, med moderat homogenitet och tidsupplösning, dessutom bättre känslighet än filmautoradiografi. Realtidsregisteringar av radioaktiva biomedicinska preparat har genomförts för olika applikationer.
Den öppna detektorytan (scintillatorn) medger utrymme för applikationer inom ett stort antal olika områden. I den här avhandlingen demonstreras olika exempel av tillämplingar såsom avbildning av tumörer, normal vävnad och levande celler (nerver), såväl för alfa-emitterande preparat från omgivningsprover.
Den utvecklade Betakameran har visat sig vara ett komplement till den tradionella film-autoradiografin, med snabb digital registrering i realtid. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/466441
- author
- Ljunggren, Kaj LU
- supervisor
- opponent
-
- Prof Lundqvist, Hans, Uppsala
- organization
- publishing date
- 2003
- type
- Thesis
- publication status
- published
- subject
- keywords
- Klinisk fysiologi, radiologi, tomografi, medicinsk instrumentering, medical instrumentation, tomography, radiology, Clinical physics, microchannel plate, radionuclides, scintillator, autoradiography, Beta Camera
- pages
- 37 pages
- publisher
- Department of Medical Radiation Physics, Clinical Sciences, Lund, Lund University
- defense location
- Oncology Dept., Lund University Hospital
- defense date
- 2003-12-16 10:15:00
- external identifiers
-
- other:ISRN: LUJI-RADFYS-AVH-6/2003
- ISBN
- 91-974444-5-6
- language
- English
- LU publication?
- yes
- additional info
- Article: Ljunggren K and Strand S-E. "Beta Camera for Static and Dynamic Imaging of Charged-Particle Emitting Radionuclides in Biologic Samples". J. Nucl. Med., 31, 2058-2063, 1990. Article: Ljunggren K and Strand S-E. "Imaging Detector for Static and Dynamic Studies in Biological Samples". Nucl. Instr. and Meth., A310, 475-478, 1991. Article: Ljunggren K, Strand S-E, Ceberg CP, Sjöholm H, Elmqvist D, Brun A and Salford LG. "Beta Camera Low-Activity Tumor Imaging". Acta Oncologica, 32, 869-872, 1993. Article: Ljunggren K and Strand S-E. "Reduction of Noise in the Beta Camera for Low Activity applications". IEEE Transactions on Nuclear Science, 41,1666-1667, 1994. Article: Ljunggren K, Strand S-E, Ivanovic M, Francheschi D, Weber D, Dilmanian A and Coderre J. "Conversion Electron Imaging of Tc-99m with a Beta Camera". Submitted to Medical Physics, 2003. Article: Sjöholm H, Ljunggren K, Adeli R, Brun A, Ceberg C, Strand S-E and Salford LG. "Necrosis of Malignant Gliomas After Intratumoral Injection of 201 Tl In Vivo in the Rat". Anti-Cancer Drugs, 6, 109-114, 1995.
- id
- 93a4ecb4-d199-46f5-87b9-1ab177f7a7f7 (old id 466441)
- date added to LUP
- 2016-04-04 11:45:39
- date last changed
- 2018-11-21 21:07:00
@phdthesis{93a4ecb4-d199-46f5-87b9-1ab177f7a7f7,
abstract = {{A new detector for on-line digital detection of charged particles (beta-particles, conversion electrons and alpha-particles) from thin samples for rapid autoradiography has been developed; the Beta Camera. The device consists of a photon-sensitive detector (image photon detector, IPD); the main component of which is a microchannel plate. The sample to be measured is mounted in close contact to a thin scintillator on the IPD. Electrons are generated from the photocathode and the electron avalanche through the microchannel plate is registered by a resistive anode. The results are stored in an image memory for visual studies and further processing.<br/><br>
<br/><br>
The detector has a linear response making quantification easy. Results show that the Beta Camera can image radionuclide distributions with a spatial resolution of 500 µm, has good homogeneity and time resolution, and better sensitivy than film autoradiography. Biomedical samples have been imaged with the Beta Camera in several applications in real time.<br/><br>
<br/><br>
The open face of the detector (the scintillator) gives considerable freedom allowing a wide range of applications. In this thesis various examples of the use of the Beta Camera are given, such as imaging of tumours, normal tissues and living cells (nerves), as well as alpha-emitting environmental samples.<br/><br>
<br/><br>
The Beta Camera developed in this work has shown to provide a complement to ordinary filmautoradiography, but with fast, real-time and digital registration of radionuclide distributions.}},
author = {{Ljunggren, Kaj}},
isbn = {{91-974444-5-6}},
keywords = {{Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering; medical instrumentation; tomography; radiology; Clinical physics; microchannel plate; radionuclides; scintillator; autoradiography; Beta Camera}},
language = {{eng}},
publisher = {{Department of Medical Radiation Physics, Clinical Sciences, Lund, Lund University}},
school = {{Lund University}},
title = {{Beta Camera: Development and applications.}},
year = {{2003}},
}