Association between sickle cell trait and the prevalence and severity of diabetic retinopathy
Harbi, Majed Al ; Khandekar, Rajiv ; Kozak, Igor and Schatz, Patrik LU
(2016)
In PLoS ONE
11(7).
- Abstract
Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the prevalence of sight threatening DR [here defined as diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR)], between the SCT and control groups. Secondary outcome measures included differences in visual acuity, ocular comorbidities, intraocular pressure, glycemic control as assessed by random blood glucose measurement,... (More)
Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the prevalence of sight threatening DR [here defined as diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR)], between the SCT and control groups. Secondary outcome measures included differences in visual acuity, ocular comorbidities, intraocular pressure, glycemic control as assessed by random blood glucose measurement, diabetes duration, nephropathy, hyperlipidemia and hypertension. Results The SCT group had statistically significantly shorter duration of DM (median [25% quartile] 15 [8.3] years versus 20 [14.7] years, respectively)(P
(Less)
- author
- Harbi, Majed Al
; Khandekar, Rajiv
; Kozak, Igor
and Schatz, Patrik
LU
- organization
- publishing date
- 2016-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 11
- issue
- 7
- article number
- e0159215
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:84978514909
- wos:000379579500099
- pmid:27414024
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0159215
- language
- English
- LU publication?
- yes
- id
- 4731bf7b-afd9-427a-a246-fa833b92c716
- date added to LUP
- 2016-08-02 10:37:46
- date last changed
- 2024-02-02 21:40:18
@article{4731bf7b-afd9-427a-a246-fa833b92c716,
abstract = {{<p>Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the prevalence of sight threatening DR [here defined as diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR)], between the SCT and control groups. Secondary outcome measures included differences in visual acuity, ocular comorbidities, intraocular pressure, glycemic control as assessed by random blood glucose measurement, diabetes duration, nephropathy, hyperlipidemia and hypertension. Results The SCT group had statistically significantly shorter duration of DM (median [25% quartile] 15 [8.3] years versus 20 [14.7] years, respectively)(P</p>}},
author = {{Harbi, Majed Al and Khandekar, Rajiv and Kozak, Igor and Schatz, Patrik}},
issn = {{1932-6203}},
language = {{eng}},
month = {{07}},
number = {{7}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Association between sickle cell trait and the prevalence and severity of diabetic retinopathy}},
url = {{http://dx.doi.org/10.1371/journal.pone.0159215}},
doi = {{10.1371/journal.pone.0159215}},
volume = {{11}},
year = {{2016}},
}