HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
Odermarsky, Michal LU
; Pesonen, Erkki
LU
; Sorsa, Timo
; Lernmark, Åke
LU
; Pussinen, Pirkko
and Liuba, Petru
LU
(2018)
In Acta Diabetologica
55(1).
p.41-47
- Abstract
- Aims
This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Methods
Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results
cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62)... (More) - Aims
This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).
Methods
Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results
cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.
Conclusions
The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/47b9d9bd-5a73-4a33-9750-3b8590dd6905
- author
- Odermarsky, Michal
LU
; Pesonen, Erkki
LU
; Sorsa, Timo
; Lernmark, Åke
LU
; Pussinen, Pirkko
and Liuba, Petru
LU
- organization
- publishing date
- 2018-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Diabetologica
- volume
- 55
- issue
- 1
- pages
- 7 pages
- publisher
- Springer
- external identifiers
-
- scopus:85031995595
- pmid:29064046
- ISSN
- 1432-5233
- DOI
- 10.1007/s00592-017-1063-1
- language
- English
- LU publication?
- yes
- id
- 47b9d9bd-5a73-4a33-9750-3b8590dd6905
- date added to LUP
- 2017-10-24 14:41:31
- date last changed
- 2024-01-14 08:10:24
@article{47b9d9bd-5a73-4a33-9750-3b8590dd6905,
abstract = {{Aims<br>
<br>
This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).<br>
Methods<br>
<br>
Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.<br>
Results<br>
<br>
cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = − 0.3; n = 62) and FMD (p = 0.03, r = − 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.<br>
Conclusions<br>
<br>
The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.}},
author = {{Odermarsky, Michal and Pesonen, Erkki and Sorsa, Timo and Lernmark, Åke and Pussinen, Pirkko and Liuba, Petru}},
issn = {{1432-5233}},
language = {{eng}},
number = {{1}},
pages = {{41--47}},
publisher = {{Springer}},
series = {{Acta Diabetologica}},
title = {{HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes}},
url = {{http://dx.doi.org/10.1007/s00592-017-1063-1}},
doi = {{10.1007/s00592-017-1063-1}},
volume = {{55}},
year = {{2018}},
}