Hypertension in adults with repaired coarctation of the aorta
(2016) In American Heart Journal 181. p.10-15- Abstract
Aims In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. Methods and results In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 ± 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an... (More)
Aims In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. Methods and results In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 ± 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and >20 mmHg, in comparison to the interval ≤10 mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (≥140/90 mmHg) without having been diagnosed with HTN were excluded from the analyses. Conclusions Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.
(Less)
- author
- Rinnström, Daniel ; Dellborg, Mikael ; Thilén, Ulf LU ; Sörensson, Peder ; Nielsen, Niels Erik ; Christersson, Christina and Johansson, Bengt
- organization
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Heart Journal
- volume
- 181
- pages
- 6 pages
- publisher
- Mosby-Elsevier
- external identifiers
-
- scopus:84984924272
- wos:000387253900004
- pmid:27823680
- ISSN
- 0002-8703
- DOI
- 10.1016/j.ahj.2016.07.012
- language
- English
- LU publication?
- yes
- id
- 4c0dc6c3-377a-4dc8-96aa-10a7c15b49a4
- date added to LUP
- 2016-09-28 16:02:38
- date last changed
- 2024-04-05 07:12:13
@article{4c0dc6c3-377a-4dc8-96aa-10a7c15b49a4,
abstract = {{<p>Aims In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. Methods and results In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 ± 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and >20 mmHg, in comparison to the interval ≤10 mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (≥140/90 mmHg) without having been diagnosed with HTN were excluded from the analyses. Conclusions Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.</p>}},
author = {{Rinnström, Daniel and Dellborg, Mikael and Thilén, Ulf and Sörensson, Peder and Nielsen, Niels Erik and Christersson, Christina and Johansson, Bengt}},
issn = {{0002-8703}},
language = {{eng}},
month = {{11}},
pages = {{10--15}},
publisher = {{Mosby-Elsevier}},
series = {{American Heart Journal}},
title = {{Hypertension in adults with repaired coarctation of the aorta}},
url = {{http://dx.doi.org/10.1016/j.ahj.2016.07.012}},
doi = {{10.1016/j.ahj.2016.07.012}},
volume = {{181}},
year = {{2016}},
}