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Factors limiting physical working capacity in predialytic uraemic patients

Clyne, N. LU orcid ; Jogestrand, T. ; Lins, L. E. ; Pehrsson, S. K. and Ekelund, L. G. (1987) In Acta Medica Scandinavica 222(2). p.183-190
Abstract

The exercise capacity of 20 predialytic uraemic patients (mean age 43 ± 12 years) was studied prospectively. Nine of these patients were examined twice in a longitudinal study. The maximal working capacity, measured by standardized exercise test on a bicycle ergometer, averaged 74 ± 19% of the expected normal. Normal exercise ECG were registered in 16 out of 20 patients. Total hemoglobin/kg body weight (THb) was 67 ± 16% of the expected normal and serum parathyroid hormone concentration (PTH) was 39 ± 39 μg/l (normal range 0.5-1.5). Partial correlation showed a correlation between exercise capacity and PTH (p <0.05). In the longitudinal study the decrease in steady state exercise capacity was correlated to the decrease in THb (p... (More)

The exercise capacity of 20 predialytic uraemic patients (mean age 43 ± 12 years) was studied prospectively. Nine of these patients were examined twice in a longitudinal study. The maximal working capacity, measured by standardized exercise test on a bicycle ergometer, averaged 74 ± 19% of the expected normal. Normal exercise ECG were registered in 16 out of 20 patients. Total hemoglobin/kg body weight (THb) was 67 ± 16% of the expected normal and serum parathyroid hormone concentration (PTH) was 39 ± 39 μg/l (normal range 0.5-1.5). Partial correlation showed a correlation between exercise capacity and PTH (p <0.05). In the longitudinal study the decrease in steady state exercise capacity was correlated to the decrease in THb (p <0.05), but not to the increase in PTH. In conclusion, patients with predialytic uraemia have a reduced maximal working capacity, due to several possible factors one of which is a reduced THb. Ischaemic heart disease seems to be of minor importance.

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author
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publishing date
type
Contribution to journal
publication status
published
in
Acta Medica Scandinavica
volume
222
issue
2
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0023183584
  • pmid:3673671
ISSN
0001-6101
language
English
LU publication?
no
id
4d5104ac-f3ea-4b70-b1a3-a832c0157665
date added to LUP
2016-08-30 22:10:31
date last changed
2024-01-19 08:10:07
@article{4d5104ac-f3ea-4b70-b1a3-a832c0157665,
  abstract     = {{<p>The exercise capacity of 20 predialytic uraemic patients (mean age 43 ± 12 years) was studied prospectively. Nine of these patients were examined twice in a longitudinal study. The maximal working capacity, measured by standardized exercise test on a bicycle ergometer, averaged 74 ± 19% of the expected normal. Normal exercise ECG were registered in 16 out of 20 patients. Total hemoglobin/kg body weight (THb) was 67 ± 16% of the expected normal and serum parathyroid hormone concentration (PTH) was 39 ± 39 μg/l (normal range 0.5-1.5). Partial correlation showed a correlation between exercise capacity and PTH (p &lt;0.05). In the longitudinal study the decrease in steady state exercise capacity was correlated to the decrease in THb (p &lt;0.05), but not to the increase in PTH. In conclusion, patients with predialytic uraemia have a reduced maximal working capacity, due to several possible factors one of which is a reduced THb. Ischaemic heart disease seems to be of minor importance.</p>}},
  author       = {{Clyne, N. and Jogestrand, T. and Lins, L. E. and Pehrsson, S. K. and Ekelund, L. G.}},
  issn         = {{0001-6101}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{183--190}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Medica Scandinavica}},
  title        = {{Factors limiting physical working capacity in predialytic uraemic patients}},
  volume       = {{222}},
  year         = {{1987}},
}