Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors.
(2007) In Journal of Internal Medicine 261(6). p.511-528- Abstract
- The innate immunity plays a critical role in host protection against pathogens and it relies amongst others on pattern recognition receptors such as the Toll-like receptors (TLRs) and the nucleotide-binding oligomerization domains proteins (NOD-like receptors, NLRs) to alert the immune system of the presence of invading bacteria. Since their recent discovery less than a decade ago, both TLRs and NLRs have been shown to be crucial in host protection against microbial infections but also in homeostasis of the colonizing microflora. They recognize specific microbial ligands and with the use of distinct adaptor molecules, they activate different signalling pathways that in turns trigger subsequent inflammatory and immune responses that allows... (More)
- The innate immunity plays a critical role in host protection against pathogens and it relies amongst others on pattern recognition receptors such as the Toll-like receptors (TLRs) and the nucleotide-binding oligomerization domains proteins (NOD-like receptors, NLRs) to alert the immune system of the presence of invading bacteria. Since their recent discovery less than a decade ago, both TLRs and NLRs have been shown to be crucial in host protection against microbial infections but also in homeostasis of the colonizing microflora. They recognize specific microbial ligands and with the use of distinct adaptor molecules, they activate different signalling pathways that in turns trigger subsequent inflammatory and immune responses that allows a immediate response towards bacterial infections and the initiation of the long-lasting adaptive immunity. In this review, we will focus on the role of the TLRs against bacterial infections in humans in contrast to mice that have been used extensively in experimental models of infections and discuss their role in controlling normal flora or nonpathogenic bacteria. We also highlight how bacteria can evade recognition by TLRs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/540014
- author
- Albiger, Barbara LU ; Dahlberg, S ; Henriques-Normark, B and Normark, S
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Immunity, Humans, Bacterial Infections: immunology, Signal Transduction: physiology, Mice, Intestines: microbiology, Intestines: immunology, Natural, Animals, Toll-Like Receptors: metabolism, Species Specificity
- in
- Journal of Internal Medicine
- volume
- 261
- issue
- 6
- pages
- 511 - 528
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000246803400001
- scopus:34249732658
- ISSN
- 1365-2796
- DOI
- 10.1111/j.1365-2796.2007.01821.x
- language
- English
- LU publication?
- yes
- id
- 73e6c9f0-e5c8-4c21-8505-2bad1d2cc6a6 (old id 540014)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17547708&dopt=Abstract
- date added to LUP
- 2016-04-04 09:06:07
- date last changed
- 2022-03-23 03:52:03
@article{73e6c9f0-e5c8-4c21-8505-2bad1d2cc6a6,
abstract = {{The innate immunity plays a critical role in host protection against pathogens and it relies amongst others on pattern recognition receptors such as the Toll-like receptors (TLRs) and the nucleotide-binding oligomerization domains proteins (NOD-like receptors, NLRs) to alert the immune system of the presence of invading bacteria. Since their recent discovery less than a decade ago, both TLRs and NLRs have been shown to be crucial in host protection against microbial infections but also in homeostasis of the colonizing microflora. They recognize specific microbial ligands and with the use of distinct adaptor molecules, they activate different signalling pathways that in turns trigger subsequent inflammatory and immune responses that allows a immediate response towards bacterial infections and the initiation of the long-lasting adaptive immunity. In this review, we will focus on the role of the TLRs against bacterial infections in humans in contrast to mice that have been used extensively in experimental models of infections and discuss their role in controlling normal flora or nonpathogenic bacteria. We also highlight how bacteria can evade recognition by TLRs.}},
author = {{Albiger, Barbara and Dahlberg, S and Henriques-Normark, B and Normark, S}},
issn = {{1365-2796}},
keywords = {{Immunity; Humans; Bacterial Infections: immunology; Signal Transduction: physiology; Mice; Intestines: microbiology; Intestines: immunology; Natural; Animals; Toll-Like Receptors: metabolism; Species Specificity}},
language = {{eng}},
number = {{6}},
pages = {{511--528}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors.}},
url = {{https://lup.lub.lu.se/search/files/5231968/626023.pdf}},
doi = {{10.1111/j.1365-2796.2007.01821.x}},
volume = {{261}},
year = {{2007}},
}