The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies.
Andersson, M ; Hansson, Oskar LU
; Minthon, Lennart
LU
; Ballard, C G
and Londos, Elisabet
LU
(2008)
In International Journal of Geriatric Psychiatry
23(2).
p.192-198
- Abstract
- OBJECTIVES: To determine whether orthostatic hypotension (OH) is more common in patients with dementia than in older people without cognitive impairment and to identify key differences in the profile of the orthostatic response and the pulse drive during orthostatic challenge between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). METHODS: The orthostatic response was evaluated in 235 patients with AD, 52 patients with DLB and 62 elderly controls. The blood pressure and pulse rate were measured in supine position, immediately after standing up and after 1, 3, 5 and 10 min of standing. OH was defined as a reduction of systolic blood pressure (SBP) of at least 20 mm Hg or a reduction of diastolic blood pressure (DBP) of at... (More)
- OBJECTIVES: To determine whether orthostatic hypotension (OH) is more common in patients with dementia than in older people without cognitive impairment and to identify key differences in the profile of the orthostatic response and the pulse drive during orthostatic challenge between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). METHODS: The orthostatic response was evaluated in 235 patients with AD, 52 patients with DLB and 62 elderly controls. The blood pressure and pulse rate were measured in supine position, immediately after standing up and after 1, 3, 5 and 10 min of standing. OH was defined as a reduction of systolic blood pressure (SBP) of at least 20 mm Hg or a reduction of diastolic blood pressure (DBP) of at least 10 mm Hg. RESULTS: OH occurred in 69% of the DLB patients and in 42% of the AD patients, but only in 13% of the controls (p < 0.001 controls vs AD and controls vs DLB, p = 0.001 AD vs DLB) The DLB patients had a greater drop in SBP than the other study groups during orthostatic challenge and had a more prolonged period of orthostasis. The pulse drive on orthostatic challenge was similar in between groups. However, in the DLB group it was not adequate to restore the blood pressure to supine values. CONCLUSIONS: Patients with DLB react different to orthostatic challenge than patients with AD or controls, with important clinical implications for key disease symptoms and treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/540901
- author
- Andersson, M
; Hansson, Oskar
LU
; Minthon, Lennart
LU
; Ballard, C G
and Londos, Elisabet
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dementia, hypotension, orthostatic, Lewy bodies
- in
- International Journal of Geriatric Psychiatry
- volume
- 23
- issue
- 2
- pages
- 192 - 198
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000253472100011
- pmid:17621385
- scopus:39749176349
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.1861
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Psychiatry/Primary Care/Public Health (013240500)
- id
- e89f955c-2111-4f2f-b12c-abb6e0a956c7 (old id 540901)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17621385&dopt=Abstract
- date added to LUP
- 2016-04-01 12:31:45
- date last changed
- 2022-01-27 06:21:54
@article{e89f955c-2111-4f2f-b12c-abb6e0a956c7,
abstract = {{OBJECTIVES: To determine whether orthostatic hypotension (OH) is more common in patients with dementia than in older people without cognitive impairment and to identify key differences in the profile of the orthostatic response and the pulse drive during orthostatic challenge between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). METHODS: The orthostatic response was evaluated in 235 patients with AD, 52 patients with DLB and 62 elderly controls. The blood pressure and pulse rate were measured in supine position, immediately after standing up and after 1, 3, 5 and 10 min of standing. OH was defined as a reduction of systolic blood pressure (SBP) of at least 20 mm Hg or a reduction of diastolic blood pressure (DBP) of at least 10 mm Hg. RESULTS: OH occurred in 69% of the DLB patients and in 42% of the AD patients, but only in 13% of the controls (p < 0.001 controls vs AD and controls vs DLB, p = 0.001 AD vs DLB) The DLB patients had a greater drop in SBP than the other study groups during orthostatic challenge and had a more prolonged period of orthostasis. The pulse drive on orthostatic challenge was similar in between groups. However, in the DLB group it was not adequate to restore the blood pressure to supine values. CONCLUSIONS: Patients with DLB react different to orthostatic challenge than patients with AD or controls, with important clinical implications for key disease symptoms and treatment.}},
author = {{Andersson, M and Hansson, Oskar and Minthon, Lennart and Ballard, C G and Londos, Elisabet}},
issn = {{1099-1166}},
keywords = {{dementia; hypotension; orthostatic; Lewy bodies}},
language = {{eng}},
number = {{2}},
pages = {{192--198}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Geriatric Psychiatry}},
title = {{The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies.}},
url = {{https://lup.lub.lu.se/search/files/2960077/626073.pdf}},
doi = {{10.1002/gps.1861}},
volume = {{23}},
year = {{2008}},
}