The emerging complexity of gene fusions in cancer.
Mertens, Fredrik LU ; Johansson, Bertil LU ; Fioretos, Thoas LU and Mitelman, Felix LU
(2015)
In Nature Reviews. Cancer
15(6).
p.371-381
- Abstract
- Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In... (More)
- Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In this Timeline article, we describe the spectrum of gene fusions in cancer and how the methods to identify them have evolved, and also discuss conceptual implications of current, sequencing-based approaches for detection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5442683
- author
- Mertens, Fredrik
LU
; Johansson, Bertil
LU
; Fioretos, Thoas
LU
and Mitelman, Felix
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews. Cancer
- volume
- 15
- issue
- 6
- pages
- 371 - 381
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:25998716
- wos:000354962600010
- scopus:84929858006
- pmid:25998716
- ISSN
- 1474-1768
- DOI
- 10.1038/nrc3947
- language
- English
- LU publication?
- yes
- id
- 32ce9f90-426a-4f4d-aaf7-ffae01f4e979 (old id 5442683)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25998716?dopt=Abstract
- date added to LUP
- 2016-04-01 10:28:23
- date last changed
- 2022-06-30 02:29:03
@article{32ce9f90-426a-4f4d-aaf7-ffae01f4e979,
abstract = {{Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In this Timeline article, we describe the spectrum of gene fusions in cancer and how the methods to identify them have evolved, and also discuss conceptual implications of current, sequencing-based approaches for detection.}},
author = {{Mertens, Fredrik and Johansson, Bertil and Fioretos, Thoas and Mitelman, Felix}},
issn = {{1474-1768}},
language = {{eng}},
number = {{6}},
pages = {{371--381}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews. Cancer}},
title = {{The emerging complexity of gene fusions in cancer.}},
url = {{http://dx.doi.org/10.1038/nrc3947}},
doi = {{10.1038/nrc3947}},
volume = {{15}},
year = {{2015}},
}