Association between Erectile Function and Biomarkers of Subclinical Atherosclerosis : A Study Based on Middle-Aged Healthy Men from the General Population
(2016) In Current Urology 9(3). p.119-123- Abstract
Introduction: Epidemiological studies suggest atherosclerosis as a common risk factor between cardiovascular diseases and erectile dysfunction (ED). We aimed to determine the association between erectile function and the biomarkers of subclinical atherosclerosis in 119 middle-aged healthy men from the general population. Methods: Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5). Serum levels of biomarkers of atherosclerosis: Apolipoprotein A, Apolipoprotein B, fibrinogen, and C-reactive protein (CRP) were measured. In addition, demographic data was collected. Results: The mean (SD) of age was 55 years (± 4.0). The prevalence of ED was 50%. There was a negative significant correlation between... (More)
Introduction: Epidemiological studies suggest atherosclerosis as a common risk factor between cardiovascular diseases and erectile dysfunction (ED). We aimed to determine the association between erectile function and the biomarkers of subclinical atherosclerosis in 119 middle-aged healthy men from the general population. Methods: Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5). Serum levels of biomarkers of atherosclerosis: Apolipoprotein A, Apolipoprotein B, fibrinogen, and C-reactive protein (CRP) were measured. In addition, demographic data was collected. Results: The mean (SD) of age was 55 years (± 4.0). The prevalence of ED was 50%. There was a negative significant correlation between IIEF-5 and CRP levels (r = -0.20, p = 0.02), and BMI (r = -0.20, p = 0.03), respectively. No significant correlations between IIEF-5 and serum levels of Apolipoprotein A, Apolipoprotein B, and fibrinogen were found (p > 0.05). A positive significant correlation was found between BMI and fibrinogen (r = 0.20, p = 0.01), CRP (r = 0.30, p = 0.001). In a multivariate logistic regression model with IIEF-5 as the dependent variable, CRP was the only biomarker that predicted ED (odds ratio = 1.350; 95 % CI: 1.044-1.754). Conclusions: These results indicate that CRP is a biomarker of subclinical atherosclerosis associated with ED. This association seems to be linked to greater BMI among such men.
(Less)
- author
- Elzanaty, Saad LU ; REZANEZHAD ZANJANI, BABAK LU ; Willenheimer, Ronnie LU and Borgquist, Rasmus LU
- organization
-
- Urological research, Malmö (research group)
- Department of Translational Medicine
- Medicine, Lund
- Arrhytmias and Cardiac Device treatment (research group)
- Cardiology Research Group (research group)
- Cardiology
- Electrocardiology Research Group - CIEL (research group)
- Clinical studies af Atrial Fibrillation (research group)
- publishing date
- 2016-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atherosclerosis, CRP, Erectile dysfunction, Obesity
- in
- Current Urology
- volume
- 9
- issue
- 3
- pages
- 119 - 123
- publisher
- Karger
- external identifiers
-
- pmid:27867328
- scopus:84992380030
- ISSN
- 1661-7649
- DOI
- 10.1159/000442865
- language
- English
- LU publication?
- yes
- id
- 5ac82dfe-ff8f-4818-a6c6-5b01b5a50dca
- date added to LUP
- 2016-11-16 15:56:41
- date last changed
- 2024-02-03 04:22:00
@article{5ac82dfe-ff8f-4818-a6c6-5b01b5a50dca, abstract = {{<p>Introduction: Epidemiological studies suggest atherosclerosis as a common risk factor between cardiovascular diseases and erectile dysfunction (ED). We aimed to determine the association between erectile function and the biomarkers of subclinical atherosclerosis in 119 middle-aged healthy men from the general population. Methods: Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5). Serum levels of biomarkers of atherosclerosis: Apolipoprotein A, Apolipoprotein B, fibrinogen, and C-reactive protein (CRP) were measured. In addition, demographic data was collected. Results: The mean (SD) of age was 55 years (± 4.0). The prevalence of ED was 50%. There was a negative significant correlation between IIEF-5 and CRP levels (r = -0.20, p = 0.02), and BMI (r = -0.20, p = 0.03), respectively. No significant correlations between IIEF-5 and serum levels of Apolipoprotein A, Apolipoprotein B, and fibrinogen were found (p > 0.05). A positive significant correlation was found between BMI and fibrinogen (r = 0.20, p = 0.01), CRP (r = 0.30, p = 0.001). In a multivariate logistic regression model with IIEF-5 as the dependent variable, CRP was the only biomarker that predicted ED (odds ratio = 1.350; 95 % CI: 1.044-1.754). Conclusions: These results indicate that CRP is a biomarker of subclinical atherosclerosis associated with ED. This association seems to be linked to greater BMI among such men.</p>}}, author = {{Elzanaty, Saad and REZANEZHAD ZANJANI, BABAK and Willenheimer, Ronnie and Borgquist, Rasmus}}, issn = {{1661-7649}}, keywords = {{Atherosclerosis; CRP; Erectile dysfunction; Obesity}}, language = {{eng}}, month = {{10}}, number = {{3}}, pages = {{119--123}}, publisher = {{Karger}}, series = {{Current Urology}}, title = {{Association between Erectile Function and Biomarkers of Subclinical Atherosclerosis : A Study Based on Middle-Aged Healthy Men from the General Population}}, url = {{http://dx.doi.org/10.1159/000442865}}, doi = {{10.1159/000442865}}, volume = {{9}}, year = {{2016}}, }