Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium
Clyne, N. LU
; Hofman-Bang, C.
; Haga, Y.
; Hatori, N.
; Marklund, S. L.
; Pehrsson, S. K.
and Wibom, R.
(2001)
In Scandinavian Journal of Clinical & Laboratory Investigation
61(8).
p.609-614
- Abstract
Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18±4.7 U/mg protein) compared to the control rats (100±22 U/mg protein; p
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6199c653-377d-481b-91e4-f9f03dfe0cab
- author
- Clyne, N.
LU
; Hofman-Bang, C.
; Haga, Y.
; Hatori, N.
; Marklund, S. L.
; Pehrsson, S. K.
and Wibom, R.
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- keywords
- ATP production rate, Chronic cobalt toxicity, Manganese-superoxide dismutase, Rat myocardium, Superoxide radicals
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 61
- issue
- 8
- pages
- 6 pages
- publisher
- Informa Healthcare
- external identifiers
-
- scopus:0035193192
- pmid:11768320
- ISSN
- 0036-5513
- DOI
- 10.1080/003655101753267964
- language
- English
- LU publication?
- no
- id
- 6199c653-377d-481b-91e4-f9f03dfe0cab
- date added to LUP
- 2016-08-30 21:53:01
- date last changed
- 2024-04-19 08:51:42
@article{6199c653-377d-481b-91e4-f9f03dfe0cab,
abstract = {{<p>Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18±4.7 U/mg protein) compared to the control rats (100±22 U/mg protein; p </p>}},
author = {{Clyne, N. and Hofman-Bang, C. and Haga, Y. and Hatori, N. and Marklund, S. L. and Pehrsson, S. K. and Wibom, R.}},
issn = {{0036-5513}},
keywords = {{ATP production rate; Chronic cobalt toxicity; Manganese-superoxide dismutase; Rat myocardium; Superoxide radicals}},
language = {{eng}},
number = {{8}},
pages = {{609--614}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium}},
url = {{http://dx.doi.org/10.1080/003655101753267964}},
doi = {{10.1080/003655101753267964}},
volume = {{61}},
year = {{2001}},
}