Dynamic assembly of molecularly imprinted polymer nanoparticles
Gong, Haiyue LU ; Hajizadeh, Solmaz LU
; Jiang, Lingdong
LU
; Ma, Huiting
and Ye, Lei
LU
(2018)
In Journal of Colloid and Interface Science
509.
p.463-471
- Abstract
Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The... (More)
Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The imprinted polymer nanoparticles modified with boronic acid and cis-diol structures maintained high molecular binding specificity, and the nanoparticles could be induced to form dynamic particle aggregation that responded to pH variation and chemical stimuli. The possibility of modulating molecular binding and nanoparticle assembly in a mutually independent fashion can be exploited in a number of applications where repeated use of precious nanoparticles is needed.
(Less)
- author
- Gong, Haiyue
LU
; Hajizadeh, Solmaz
LU
; Jiang, Lingdong
LU
; Ma, Huiting
and Ye, Lei
LU
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Boronic acid, Dynamic assembly, Molecular imprinting, Molecular recognition, Nanoparticles
- in
- Journal of Colloid and Interface Science
- volume
- 509
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85029532399
- pmid:28923744
- ISSN
- 0021-9797
- DOI
- 10.1016/j.jcis.2017.09.046
- language
- English
- LU publication?
- yes
- id
- 6475e870-418a-4007-98e9-e78f093a5158
- date added to LUP
- 2017-09-28 14:37:03
- date last changed
- 2024-03-17 21:39:21
@article{6475e870-418a-4007-98e9-e78f093a5158,
abstract = {{<p>Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The imprinted polymer nanoparticles modified with boronic acid and cis-diol structures maintained high molecular binding specificity, and the nanoparticles could be induced to form dynamic particle aggregation that responded to pH variation and chemical stimuli. The possibility of modulating molecular binding and nanoparticle assembly in a mutually independent fashion can be exploited in a number of applications where repeated use of precious nanoparticles is needed.</p>}},
author = {{Gong, Haiyue and Hajizadeh, Solmaz and Jiang, Lingdong and Ma, Huiting and Ye, Lei}},
issn = {{0021-9797}},
keywords = {{Boronic acid; Dynamic assembly; Molecular imprinting; Molecular recognition; Nanoparticles}},
language = {{eng}},
month = {{01}},
pages = {{463--471}},
publisher = {{Elsevier}},
series = {{Journal of Colloid and Interface Science}},
title = {{Dynamic assembly of molecularly imprinted polymer nanoparticles}},
url = {{http://dx.doi.org/10.1016/j.jcis.2017.09.046}},
doi = {{10.1016/j.jcis.2017.09.046}},
volume = {{509}},
year = {{2018}},
}