The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin
(2007) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 260(1). p.119-123- Abstract
- The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition,... (More)
- The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/647985
- author
- Pinheiro, T. ; Pallon, Jan LU ; Alves, L. C. ; Verissimo, A. ; Filipe, P. ; Silva, J. N. and Silva, R.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
- volume
- 260
- issue
- 1
- pages
- 119 - 123
- publisher
- Elsevier
- external identifiers
-
- wos:000248264900024
- scopus:34249881862
- ISSN
- 0168-583X
- DOI
- 10.1016/j.nimb.2007.02.014
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)
- id
- 3da7dc80-24f4-4172-b55c-7afd29e1cc4f (old id 647985)
- date added to LUP
- 2016-04-01 16:54:51
- date last changed
- 2022-01-28 23:01:14
@article{3da7dc80-24f4-4172-b55c-7afd29e1cc4f,
abstract = {{The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved.}},
author = {{Pinheiro, T. and Pallon, Jan and Alves, L. C. and Verissimo, A. and Filipe, P. and Silva, J. N. and Silva, R.}},
issn = {{0168-583X}},
language = {{eng}},
number = {{1}},
pages = {{119--123}},
publisher = {{Elsevier}},
series = {{Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms}},
title = {{The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin}},
url = {{http://dx.doi.org/10.1016/j.nimb.2007.02.014}},
doi = {{10.1016/j.nimb.2007.02.014}},
volume = {{260}},
year = {{2007}},
}