Real exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs
(2007) In Livestock Science 108(1-3). p.53-56- Abstract
- The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated... (More)
- The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated pancreatic enzyme preparations, thus probably recognised as dietary protein. Plasma cholecystokinin (CCK) level was lowered only by duodenal delivery of pancreatic juice. In conclusion, the results prove the existence of negative feedback mechanism regulating pancreatic secretion dependent on the presence of pure pancreatic juice or bile at the ileal level. The mechanism at the duodenal level is exclusively sensitive to pure pancreatic juice. (c) 2007 Elsevier B.V All rights reserved. (Less)
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https://lup.lub.lu.se/record/648756
- author
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ileum, pancreatic secretion, duodenum, ileal brake
- in
- Livestock Science
- volume
- 108
- issue
- 1-3
- pages
- 53 - 56
- publisher
- Elsevier
- external identifiers
-
- wos:000247123100013
- scopus:34247507732
- ISSN
- 1871-1413
- DOI
- 10.1016/j.livsci.2007.01.031
- language
- English
- LU publication?
- yes
- id
- 3f578d44-c116-4175-ada6-3df2f11a5c0e (old id 648756)
- date added to LUP
- 2016-04-01 15:23:01
- date last changed
- 2022-03-22 04:12:19
@article{3f578d44-c116-4175-ada6-3df2f11a5c0e,
abstract = {{The mechanisms involved in the down regulation of the exocrine pancreas are still not fully elucidated. The purpose of the present study was to examine the effect of duodenal and ileal exposure to pancreatic enzymes and bile on pancreatic secretion. Experiments were performed with pigs fitted with pancreatic duct, ileal and jugular vein catheters, and duodenal T-shaped cannula. A negative feedback regulation of pancreatic secretion was found for both duodenal and ileal delivery of pancreatic juice. Pancreatic secretion was unaffected by duodenal delivery of bile and bile salts, while ileal delivery of bile and bile salts lowered it. On the other hand, pancreatic secretion was increased by duodenal loading of commercial non- or activated pancreatic enzyme preparations, thus probably recognised as dietary protein. Plasma cholecystokinin (CCK) level was lowered only by duodenal delivery of pancreatic juice. In conclusion, the results prove the existence of negative feedback mechanism regulating pancreatic secretion dependent on the presence of pure pancreatic juice or bile at the ileal level. The mechanism at the duodenal level is exclusively sensitive to pure pancreatic juice. (c) 2007 Elsevier B.V All rights reserved.}},
author = {{Pierzynowski, Stefan and Sileikiene, V. and Valverde Piedra, J. L. and Szymanczykc, S. and Gregory, P. C. and Kruszewska, Danuta and Mosenthin, R. and Rzasa, A. and Kowalik, S. and Zabielski, R. and Weström, Björn}},
issn = {{1871-1413}},
keywords = {{ileum; pancreatic secretion; duodenum; ileal brake}},
language = {{eng}},
number = {{1-3}},
pages = {{53--56}},
publisher = {{Elsevier}},
series = {{Livestock Science}},
title = {{Real exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs}},
url = {{http://dx.doi.org/10.1016/j.livsci.2007.01.031}},
doi = {{10.1016/j.livsci.2007.01.031}},
volume = {{108}},
year = {{2007}},
}