Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia

Lee, Benjamin H. ; Tothova, Zuzana ; Levine, Ross L. ; Anderson, Kristina LU ; Buza-Vidas, Natalija LU ; Cullen, Dana E. ; McDowell, Elizabeth P. ; Adelsperger, Jennifer ; Frhling, Stefan and Huntly, Brian J. P. , et al. (2007) In Cancer Cell 12(4). p.367-380
Abstract
Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive... (More)
Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Cell
volume
12
issue
4
pages
367 - 380
publisher
Cell Press
external identifiers
  • wos:000250362600010
  • scopus:35048848955
  • pmid:17936561
ISSN
1878-3686
DOI
10.1016/j.ccr.2007.08.031
language
English
LU publication?
yes
id
d3267e34-3a2c-4baf-9849-3c6b0af601c2 (old id 654162)
date added to LUP
2016-04-01 12:37:03
date last changed
2022-07-22 22:54:50
@article{d3267e34-3a2c-4baf-9849-3c6b0af601c2,
  abstract     = {{Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate.}},
  author       = {{Lee, Benjamin H. and Tothova, Zuzana and Levine, Ross L. and Anderson, Kristina and Buza-Vidas, Natalija and Cullen, Dana E. and McDowell, Elizabeth P. and Adelsperger, Jennifer and Frhling, Stefan and Huntly, Brian J. P. and Beran, Miloslav and Jacobsen, Sten Eirik W and Gilliland, D. Gary}},
  issn         = {{1878-3686}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{367--380}},
  publisher    = {{Cell Press}},
  series       = {{Cancer Cell}},
  title        = {{FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia}},
  url          = {{http://dx.doi.org/10.1016/j.ccr.2007.08.031}},
  doi          = {{10.1016/j.ccr.2007.08.031}},
  volume       = {{12}},
  year         = {{2007}},
}