The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility
(2007) In Fertility and Sterility 88(4). p.854-859- Abstract
- Objective: To determine whether the polymorphisms in aryl hydrocarbon receptor (AHR), aryl hydrocarbon receptor repressor (AHRR), and aryl hydrocarbon receptor nuclear translocator (ARNT) genes are associated with male factor infertility. Design: An association study. Setting: University research laboratory and andrology clinic. Patient(s): The subjects were infertile Estonian men (n = 112) with azoospermia or oligozoospermia and controls (n = 212) with normal sperm parameters. Intervention(s): Blood samples were obtained for DNA extraction and genotyping. Main Outcome Measure(s): AHR (Arg554Lys), AHRR (Pro 185Ala), and ARNT (G/C allele) polymorphisms were genotyped using allele-specific polymerase chain reaction. Allele and genotype... (More)
- Objective: To determine whether the polymorphisms in aryl hydrocarbon receptor (AHR), aryl hydrocarbon receptor repressor (AHRR), and aryl hydrocarbon receptor nuclear translocator (ARNT) genes are associated with male factor infertility. Design: An association study. Setting: University research laboratory and andrology clinic. Patient(s): The subjects were infertile Estonian men (n = 112) with azoospermia or oligozoospermia and controls (n = 212) with normal sperm parameters. Intervention(s): Blood samples were obtained for DNA extraction and genotyping. Main Outcome Measure(s): AHR (Arg554Lys), AHRR (Pro 185Ala), and ARNT (G/C allele) polymorphisms were genotyped using allele-specific polymerase chain reaction. Allele and genotype frequencies were compared between infertile men and controls and separately in the normozoospermia, oligozoospermia, and azoospermia groups. Result(s): The AHRR Ala185Ala genotype was implicated in susceptibility to male factor infertility. Ala/Ala genotype frequency increased in the following order: normozoospermia (18.0%), oligozoospermia (26.0%), azoospermia (42.1 %). Allele and genotype frequencies of AHR and ARNT polymorphisms were similar between cases and controls. Conclusion(s): We demonstrated that the AHRR Pro185Ala polymorphism contributed to a predisposition to male factor infertility in the Estonian population. A greater prevalence of the Ala/Ala genotype was found among infertile patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/655295
- author
- Merisalu, Ave ; Punab, Margus ; Altmae, Signe ; Haller, Kadri ; Tiido, Tarmo LU ; Peters, Maire and Salumets, Andres
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- single nucleotide polymorphisms, AHR pathway, male infertility
- in
- Fertility and Sterility
- volume
- 88
- issue
- 4
- pages
- 854 - 859
- publisher
- Elsevier
- external identifiers
-
- wos:000250192800014
- scopus:34848856384
- ISSN
- 1556-5653
- DOI
- 10.1016/j.fertnstert.2006.12.041
- language
- English
- LU publication?
- yes
- id
- 4497180d-05e5-4254-88fd-ee4698e73b74 (old id 655295)
- date added to LUP
- 2016-04-01 11:38:17
- date last changed
- 2022-01-26 07:59:56
@article{4497180d-05e5-4254-88fd-ee4698e73b74,
abstract = {{Objective: To determine whether the polymorphisms in aryl hydrocarbon receptor (AHR), aryl hydrocarbon receptor repressor (AHRR), and aryl hydrocarbon receptor nuclear translocator (ARNT) genes are associated with male factor infertility. Design: An association study. Setting: University research laboratory and andrology clinic. Patient(s): The subjects were infertile Estonian men (n = 112) with azoospermia or oligozoospermia and controls (n = 212) with normal sperm parameters. Intervention(s): Blood samples were obtained for DNA extraction and genotyping. Main Outcome Measure(s): AHR (Arg554Lys), AHRR (Pro 185Ala), and ARNT (G/C allele) polymorphisms were genotyped using allele-specific polymerase chain reaction. Allele and genotype frequencies were compared between infertile men and controls and separately in the normozoospermia, oligozoospermia, and azoospermia groups. Result(s): The AHRR Ala185Ala genotype was implicated in susceptibility to male factor infertility. Ala/Ala genotype frequency increased in the following order: normozoospermia (18.0%), oligozoospermia (26.0%), azoospermia (42.1 %). Allele and genotype frequencies of AHR and ARNT polymorphisms were similar between cases and controls. Conclusion(s): We demonstrated that the AHRR Pro185Ala polymorphism contributed to a predisposition to male factor infertility in the Estonian population. A greater prevalence of the Ala/Ala genotype was found among infertile patients.}},
author = {{Merisalu, Ave and Punab, Margus and Altmae, Signe and Haller, Kadri and Tiido, Tarmo and Peters, Maire and Salumets, Andres}},
issn = {{1556-5653}},
keywords = {{single nucleotide polymorphisms; AHR pathway; male infertility}},
language = {{eng}},
number = {{4}},
pages = {{854--859}},
publisher = {{Elsevier}},
series = {{Fertility and Sterility}},
title = {{The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility}},
url = {{http://dx.doi.org/10.1016/j.fertnstert.2006.12.041}},
doi = {{10.1016/j.fertnstert.2006.12.041}},
volume = {{88}},
year = {{2007}},
}