Extinction of conditioned blink responses by cerebello-olivary pathway stimulation
(2007) In NeuroReport 18(14). p.1479-1482- Abstract
- Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from... (More)
- Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from this investigation confirm this. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/656447
- author
- Bengtsson, Fredrik LU ; Jirenhed, Dan-Anders LU ; Svensson, Pär LU and Hesslow, Germund LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- extinction, inferior olive, unconditioned stimulus, nucleo-olivary, eyeblink conditioning
- in
- NeuroReport
- volume
- 18
- issue
- 14
- pages
- 1479 - 1482
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000249479900014
- scopus:34548087273
- ISSN
- 1473-558X
- DOI
- 10.1097/WNR.0b013e3282e326e8
- language
- English
- LU publication?
- yes
- id
- 0675c52b-8dae-4124-9bd0-37e63d3f3bf8 (old id 656447)
- date added to LUP
- 2016-04-01 11:51:42
- date last changed
- 2022-05-16 12:08:51
@article{0675c52b-8dae-4124-9bd0-37e63d3f3bf8,
abstract = {{Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from this investigation confirm this.}},
author = {{Bengtsson, Fredrik and Jirenhed, Dan-Anders and Svensson, Pär and Hesslow, Germund}},
issn = {{1473-558X}},
keywords = {{extinction; inferior olive; unconditioned stimulus; nucleo-olivary; eyeblink conditioning}},
language = {{eng}},
number = {{14}},
pages = {{1479--1482}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Extinction of conditioned blink responses by cerebello-olivary pathway stimulation}},
url = {{http://dx.doi.org/10.1097/WNR.0b013e3282e326e8}},
doi = {{10.1097/WNR.0b013e3282e326e8}},
volume = {{18}},
year = {{2007}},
}