Interpretation of serological complement biomarkers in disease
(2018) In Frontiers in Immunology 9(OCT).- Abstract
Complement system aberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complementrelated differences between patient groups and controls. However, due to the low degree of specificity and sensitivity of some of the assays used, it is not always possible to make predictions regarding the complement status of individual patients. Today, there are three main indications for determination of a patient's complement status: (1) complement... (More)
Complement system aberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complementrelated differences between patient groups and controls. However, due to the low degree of specificity and sensitivity of some of the assays used, it is not always possible to make predictions regarding the complement status of individual patients. Today, there are three main indications for determination of a patient's complement status: (1) complement deficiencies (acquired or inherited); (2) disorders with aberrant complement activation; and (3) C1 inhibitor deficiencies (acquired or inherited). An additional indication is to monitor patients on complement-regulating drugs, an indication which may be expected to increase in the near future since there is now a number of such drugs either under development, already in clinical trials or in clinical use. Available techniques to study complement include quantification of: (1) individual components; (2) activation products, (3) function, and (4) autoantibodies to complement proteins. In this review, we summarize the appropriate indications, techniques, and interpretations of basic serological complement analyses, exemplified by a number of clinical disorders.
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- author
- Ekdahl, Kristina N. ; Persson, Barbro ; Mohlin, Camilla ; Sandholm, Kerstin ; Skattum, Lillemor LU and Nilsson, Bo
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Activation products, Complement, Complement regulatory drugs, Deficiency, Functional test
- in
- Frontiers in Immunology
- volume
- 9
- issue
- OCT
- article number
- 02237
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85055834488
- pmid:30405598
- ISSN
- 1664-3224
- DOI
- 10.3389/fimmu.2018.02237
- language
- English
- LU publication?
- yes
- id
- 67799e46-cef1-4f7d-93af-068e686ecb8a
- date added to LUP
- 2018-11-15 12:11:01
- date last changed
- 2024-04-15 17:51:14
@article{67799e46-cef1-4f7d-93af-068e686ecb8a,
abstract = {{<p>Complement system aberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complementrelated differences between patient groups and controls. However, due to the low degree of specificity and sensitivity of some of the assays used, it is not always possible to make predictions regarding the complement status of individual patients. Today, there are three main indications for determination of a patient's complement status: (1) complement deficiencies (acquired or inherited); (2) disorders with aberrant complement activation; and (3) C1 inhibitor deficiencies (acquired or inherited). An additional indication is to monitor patients on complement-regulating drugs, an indication which may be expected to increase in the near future since there is now a number of such drugs either under development, already in clinical trials or in clinical use. Available techniques to study complement include quantification of: (1) individual components; (2) activation products, (3) function, and (4) autoantibodies to complement proteins. In this review, we summarize the appropriate indications, techniques, and interpretations of basic serological complement analyses, exemplified by a number of clinical disorders.</p>}},
author = {{Ekdahl, Kristina N. and Persson, Barbro and Mohlin, Camilla and Sandholm, Kerstin and Skattum, Lillemor and Nilsson, Bo}},
issn = {{1664-3224}},
keywords = {{Activation products; Complement; Complement regulatory drugs; Deficiency; Functional test}},
language = {{eng}},
number = {{OCT}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Immunology}},
title = {{Interpretation of serological complement biomarkers in disease}},
url = {{http://dx.doi.org/10.3389/fimmu.2018.02237}},
doi = {{10.3389/fimmu.2018.02237}},
volume = {{9}},
year = {{2018}},
}