Nasal indices of eosinophilic and exudative inflammation in bakery-workers
(2007) In Clinical Physiology and Functional Imaging 27(1). p.23-29- Abstract
- Aims: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. Methods: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine... (More)
- Aims: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. Methods: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine lavages were employed to explore the nasal exudative responsiveness. Results: alpha(2)-Macroglobulin and ECP increased significantly by increased workplace dust exposure (P <= 0.035). Furthermore, the exudative responsiveness to histamine increased significantly by such exposure (P <= 0.016). Similar patterns were seen in workers with occupational rhinitis and in subjects with rhinitis symptoms associated to the workplace, but not in workers with occupational sensitization. Conclusions: We conclude that occupational dust exposure in bakery-workers is associated with nasal eosinophilic exudative inflammation. In contrast, occupational sensitization is not a discriminating factor with regard to indices of eosinophilic, exudative inflammation in the present material. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/681826
- author
- Storaas, Torgeir ; Ardal, Laila ; Van Do, Thien ; Florvaag, Erik ; Steinsvag, Sverre K. ; Irgens, Agot ; Aasen, Tor B. and Greiff, Lennart LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- eosinophil cationic protein, allergy, alpha(2)-macroglobulin, airway, flour, occupational rhinitis
- in
- Clinical Physiology and Functional Imaging
- volume
- 27
- issue
- 1
- pages
- 23 - 29
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000242862200005
- scopus:33845514856
- ISSN
- 1475-0961
- DOI
- 10.1111/j.1475-097X.2007.00707.x
- language
- English
- LU publication?
- yes
- id
- 7a91a006-2a8c-4a44-9610-f55c8f9ff262 (old id 681826)
- date added to LUP
- 2016-04-01 11:41:56
- date last changed
- 2022-03-28 01:47:49
@article{7a91a006-2a8c-4a44-9610-f55c8f9ff262,
abstract = {{Aims: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. Methods: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine lavages were employed to explore the nasal exudative responsiveness. Results: alpha(2)-Macroglobulin and ECP increased significantly by increased workplace dust exposure (P <= 0.035). Furthermore, the exudative responsiveness to histamine increased significantly by such exposure (P <= 0.016). Similar patterns were seen in workers with occupational rhinitis and in subjects with rhinitis symptoms associated to the workplace, but not in workers with occupational sensitization. Conclusions: We conclude that occupational dust exposure in bakery-workers is associated with nasal eosinophilic exudative inflammation. In contrast, occupational sensitization is not a discriminating factor with regard to indices of eosinophilic, exudative inflammation in the present material.}},
author = {{Storaas, Torgeir and Ardal, Laila and Van Do, Thien and Florvaag, Erik and Steinsvag, Sverre K. and Irgens, Agot and Aasen, Tor B. and Greiff, Lennart}},
issn = {{1475-0961}},
keywords = {{eosinophil cationic protein; allergy; alpha(2)-macroglobulin; airway; flour; occupational rhinitis}},
language = {{eng}},
number = {{1}},
pages = {{23--29}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology and Functional Imaging}},
title = {{Nasal indices of eosinophilic and exudative inflammation in bakery-workers}},
url = {{http://dx.doi.org/10.1111/j.1475-097X.2007.00707.x}},
doi = {{10.1111/j.1475-097X.2007.00707.x}},
volume = {{27}},
year = {{2007}},
}