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Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

Dong, Jingran ; Tian, Hongwu ; Song, Changying ; Shi, Tiesheng and Elding, Lars Ivar LU (2018) In Dalton Transactions 47(16). p.5548-5552
Abstract
Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ormaplatin, Thiols, Reduction, Kinetics, Mechanism, Anti-cancer drug, Brönsted correlation, Linear free energy correlation
in
Dalton Transactions
volume
47
issue
16
pages
5 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:29611592
  • scopus:85045947996
ISSN
1477-9234
DOI
10.1039/c8dt00852c
language
English
LU publication?
yes
id
6913db70-66a0-4f0a-8f9f-119ef677e6c5
date added to LUP
2018-04-16 18:55:42
date last changed
2022-04-25 06:53:24
@article{6913db70-66a0-4f0a-8f9f-119ef677e6c5,
  abstract     = {{Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.}},
  author       = {{Dong, Jingran and Tian, Hongwu and Song, Changying and Shi, Tiesheng and Elding, Lars Ivar}},
  issn         = {{1477-9234}},
  keywords     = {{Ormaplatin; Thiols; Reduction; Kinetics; Mechanism; Anti-cancer drug; Brönsted correlation; Linear free energy correlation}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{16}},
  pages        = {{5548--5552}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Dalton Transactions}},
  title        = {{Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation}},
  url          = {{http://dx.doi.org/10.1039/c8dt00852c}},
  doi          = {{10.1039/c8dt00852c}},
  volume       = {{47}},
  year         = {{2018}},
}