Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers
Valind, Anders LU
; Wessman, Sandra
; Pal, Niklas
; Karlsson, Jenny
LU
; Jonson, Tord
LU
; Sandstedt, Bengt
and Gisselsson, David
LU
(2018)
In Pediatric Blood & Cancer
65(11).
- Abstract
Wilms tumors in patients with constitutional WT1 mutations are examples of Knudson's tumor suppressor paradigm, with somatic inactivation of the second allele occurring through 11p loss of heterozygosity. The time point of this second hit has remained unknown. We analyzed seven Wilms tumors from two patients with constitutional WT1 mutations by whole exome sequencing and genomic array. All tumors exhibited wild type WT1 loss through uniparental isodisomy. Each tumor had a unique genomic breakpoint in 11p, typically accompanied by a private activating mutation of CTNNB1. Hence, convergent evolution rather than field carcinogenesis underlies multifocal tumors in WT1 mutation carriers.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6fa3764d-7ddb-4cf3-98aa-e2d3fa6870cc
- author
- Valind, Anders
LU
; Wessman, Sandra
; Pal, Niklas
; Karlsson, Jenny
LU
; Jonson, Tord
LU
; Sandstedt, Bengt
and Gisselsson, David
LU
- organization
- publishing date
- 2018-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- convergent evolution, Denys–Drash syndrome, whole exome sequencing, Wilms tumor, WT1
- in
- Pediatric Blood & Cancer
- volume
- 65
- issue
- 11
- article number
- e27301
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85050620053
- pmid:29968962
- ISSN
- 1545-5009
- DOI
- 10.1002/pbc.27301
- language
- English
- LU publication?
- yes
- id
- 6fa3764d-7ddb-4cf3-98aa-e2d3fa6870cc
- date added to LUP
- 2018-10-01 10:42:04
- date last changed
- 2024-03-18 15:00:24
@article{6fa3764d-7ddb-4cf3-98aa-e2d3fa6870cc,
abstract = {{<p>Wilms tumors in patients with constitutional WT1 mutations are examples of Knudson's tumor suppressor paradigm, with somatic inactivation of the second allele occurring through 11p loss of heterozygosity. The time point of this second hit has remained unknown. We analyzed seven Wilms tumors from two patients with constitutional WT1 mutations by whole exome sequencing and genomic array. All tumors exhibited wild type WT1 loss through uniparental isodisomy. Each tumor had a unique genomic breakpoint in 11p, typically accompanied by a private activating mutation of CTNNB1. Hence, convergent evolution rather than field carcinogenesis underlies multifocal tumors in WT1 mutation carriers.</p>}},
author = {{Valind, Anders and Wessman, Sandra and Pal, Niklas and Karlsson, Jenny and Jonson, Tord and Sandstedt, Bengt and Gisselsson, David}},
issn = {{1545-5009}},
keywords = {{convergent evolution; Denys–Drash syndrome; whole exome sequencing; Wilms tumor; WT1}},
language = {{eng}},
month = {{11}},
number = {{11}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Pediatric Blood & Cancer}},
title = {{Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers}},
url = {{http://dx.doi.org/10.1002/pbc.27301}},
doi = {{10.1002/pbc.27301}},
volume = {{65}},
year = {{2018}},
}