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Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X

Haraldsson, Stefan ; Klarskov, Louise ; Nilbert, Mef LU ; Bernstein, Inge ; Bonde, Jesper and Holck, Susanne (2017) In BMC Clinical Pathology 17(1).
Abstract

Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, <... (More)

Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fcctx, Hereditary non-polyposis colorectal cancer, Immunohistochemical profile, Lynch syndrome
in
BMC Clinical Pathology
volume
17
issue
1
article number
11
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85027515565
  • pmid:28824332
  • pmid:28824332
  • wos:000407822700001
ISSN
1472-6890
DOI
10.1186/s12907-017-0052-1
language
English
LU publication?
yes
id
6fd1a333-1282-4ad7-b3e7-9e7e4e351886
date added to LUP
2017-09-04 12:02:56
date last changed
2024-03-17 20:18:24
@article{6fd1a333-1282-4ad7-b3e7-9e7e4e351886,
  abstract     = {{<p>Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p &lt; 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, &lt; 0.01, and &lt; 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.</p>}},
  author       = {{Haraldsson, Stefan and Klarskov, Louise and Nilbert, Mef and Bernstein, Inge and Bonde, Jesper and Holck, Susanne}},
  issn         = {{1472-6890}},
  keywords     = {{Fcctx; Hereditary non-polyposis colorectal cancer; Immunohistochemical profile; Lynch syndrome}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Clinical Pathology}},
  title        = {{Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X}},
  url          = {{http://dx.doi.org/10.1186/s12907-017-0052-1}},
  doi          = {{10.1186/s12907-017-0052-1}},
  volume       = {{17}},
  year         = {{2017}},
}