Depression is associated with poor prognosis in patients with chronic obstructive pulmonary disease - a systematic review
(2015) In Danish Medical Journal 62(10). p.5137-5137- Abstract
INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data.
METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with... (More)
INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data.
METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with significant methodological faults were excluded.
RESULTS: A total of 22 cohort studies were included. Of these studies, 20 were prospective, one retrospective and one was a combined retro- and prospective study. There was a tendency for studies with more patients and higher methodological quality to show a positive correlation. Sixteen of the studies showed that depression was associated with increased mortality (relative risk (RR): 1.02-3.6) and more COPD exacerbations (RR: 1.3-7.0).
CONCLUSIONS: The results showed that not only is depression a debilitating disease on its own, it also predisposes to COPD exacerbations and increased mortality in patients with COPD. Depression in patients with COPD is under-diagnosed and undertreated, and a stronger focus on the clinical significance of depression as co-morbidity is warranted.
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- author
- Salte, Kim ; Titlestad, Ingrid and Halling, Anders LU
- publishing date
- 2015-10
- type
- Contribution to journal
- publication status
- published
- keywords
- Depression/diagnosis, Disease Progression, Hospitalization, Humans, Prognosis, Pulmonary Disease, Chronic Obstructive/mortality
- in
- Danish Medical Journal
- volume
- 62
- issue
- 10
- pages
- 5137 - 5137
- publisher
- Danish Medical Association
- external identifiers
-
- pmid:26441395
- scopus:84942933064
- ISSN
- 0011-6092
- language
- English
- LU publication?
- no
- id
- 70348a61-7d3d-4891-8e06-2df6571a9214
- alternative location
- http://ugeskriftet.dk/dmj/depression-associated-poor-prognosis-patients-chronic-obstructive-pulmonary-disease-systematic
- date added to LUP
- 2019-05-27 10:35:21
- date last changed
- 2024-04-02 07:04:16
@article{70348a61-7d3d-4891-8e06-2df6571a9214,
abstract = {{<p>INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data.</p><p>METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with significant methodological faults were excluded.</p><p>RESULTS: A total of 22 cohort studies were included. Of these studies, 20 were prospective, one retrospective and one was a combined retro- and prospective study. There was a tendency for studies with more patients and higher methodological quality to show a positive correlation. Sixteen of the studies showed that depression was associated with increased mortality (relative risk (RR): 1.02-3.6) and more COPD exacerbations (RR: 1.3-7.0).</p><p>CONCLUSIONS: The results showed that not only is depression a debilitating disease on its own, it also predisposes to COPD exacerbations and increased mortality in patients with COPD. Depression in patients with COPD is under-diagnosed and undertreated, and a stronger focus on the clinical significance of depression as co-morbidity is warranted.</p>}},
author = {{Salte, Kim and Titlestad, Ingrid and Halling, Anders}},
issn = {{0011-6092}},
keywords = {{Depression/diagnosis; Disease Progression; Hospitalization; Humans; Prognosis; Pulmonary Disease, Chronic Obstructive/mortality}},
language = {{eng}},
number = {{10}},
pages = {{5137--5137}},
publisher = {{Danish Medical Association}},
series = {{Danish Medical Journal}},
title = {{Depression is associated with poor prognosis in patients with chronic obstructive pulmonary disease - a systematic review}},
url = {{http://ugeskriftet.dk/dmj/depression-associated-poor-prognosis-patients-chronic-obstructive-pulmonary-disease-systematic}},
volume = {{62}},
year = {{2015}},
}