Hospital admissions for orthostatic hypotension and syncope in later life : insights from the Malmö Preventive Project
Ricci, Fabrizio ; Manzoli, Lamberto ; Sutton, Richard ; Melander, Olle LU
; Flacco, Maria E.
; Gallina, Sabina
; de Caterina, Raffaele
and Fedorowski, Artur
LU
(2017)
In Journal of Hypertension
35(4).
p.776-783
- Abstract
OBJECTIVE(S):: We explored incidence, predictors, and long-term prognosis of hospital admissions attributed to reflex syncope and orthostatic hypotension. METHODS:: We analyzed a cohort of 32?628 individuals (68.2% men; age, 45.6?±?7.4 years) without prevalent cardiovascular disease over a follow-up period of 26.6?±?7.5 years. RESULTS:: One thousand and fourteen persons (3.1%, 1.2 per 1000 person-years) had at least 1 hospitalization for orthostatic hypotension (n?=?462, 1.42%) or syncope (n?=?632, 1.94%). Orthostatic hypotension-related hospitalizations were predicted by age [per 1-year increase, hazard ratio 1.14, 95% confidence interval (CI): 1.12–1.16], smoking (hazard ratio 1.35, 95% CI: 1.12–1.64), diabetes (hazard ratio 1.50, 95%... (More)
OBJECTIVE(S):: We explored incidence, predictors, and long-term prognosis of hospital admissions attributed to reflex syncope and orthostatic hypotension. METHODS:: We analyzed a cohort of 32?628 individuals (68.2% men; age, 45.6?±?7.4 years) without prevalent cardiovascular disease over a follow-up period of 26.6?±?7.5 years. RESULTS:: One thousand and fourteen persons (3.1%, 1.2 per 1000 person-years) had at least 1 hospitalization for orthostatic hypotension (n?=?462, 1.42%) or syncope (n?=?632, 1.94%). Orthostatic hypotension-related hospitalizations were predicted by age [per 1-year increase, hazard ratio 1.14, 95% confidence interval (CI): 1.12–1.16], smoking (hazard ratio 1.35, 95% CI: 1.12–1.64), diabetes (hazard ratio 1.50, 95% CI: 1.00–2.25), baseline orthostatic hypotension (hazard ratio 1.45, 95% CI: 1.05–1.98), in particular, by SBP fall at least 30?mmHg (hazard ratio 3.93, 95% CI: 2.14–7.23), whereas syncope hospitalizations by age (per 1-year increase, hazard ratio 1.09, 95% CI: 1.07–1.11), smoking (hazard ratio 1.27, 95% CI: 1.08–1.49), and hypertension (hazard ratio 1.42, 95% CI: 1.20–1.69). Both syncope-hospitalized and orthostatic hypotension hospitalized patients had higher burden of hospital admissions for other reasons such as cardiovascular, pulmonary, renal disease, or diabetes. During the follow-up, 10?727 (32.9%) died, with 419 deaths preceded by syncope/orthostatic hypotension hospitalization. After adjustment for traditional risk factors, syncope-hospitalization predicted all-cause mortality (hazard ratio 1.16, 95% CI: 1.02–1.31), whereas orthostatic hypotension hospitalization predicted cardiovascular mortality (hazard ratio 1.13, 95% CI: 1.07–1.19). CONCLUSION:: Hospital admissions due to syncope and orthostatic hypotension occur in ≈3% of older individuals and increase with age and comorbidities. Admissions due to syncope are associated with prevalent hypertension, whereas those due to orthostatic hypotension overlap with diabetes and previously identified orthostatic hypotension. Syncope-related admissions predict higher all-cause mortality, whereas orthostatic hypotension-related admissions herald increased cardiovascular mortality.
(Less)
- author
- Ricci, Fabrizio
; Manzoli, Lamberto
; Sutton, Richard
; Melander, Olle
LU
; Flacco, Maria E.
; Gallina, Sabina
; de Caterina, Raffaele
and Fedorowski, Artur
LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hypertension
- volume
- 35
- issue
- 4
- pages
- 776 - 783
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85007238122
- pmid:28009704
- wos:000395903600019
- ISSN
- 0263-6352
- DOI
- 10.1097/HJH.0000000000001215
- language
- English
- LU publication?
- yes
- id
- 768d0d04-e389-4c67-ace0-4ad50f2c6134
- date added to LUP
- 2017-01-13 08:06:15
- date last changed
- 2024-04-19 16:56:54
@article{768d0d04-e389-4c67-ace0-4ad50f2c6134,
abstract = {{<p>OBJECTIVE(S):: We explored incidence, predictors, and long-term prognosis of hospital admissions attributed to reflex syncope and orthostatic hypotension. METHODS:: We analyzed a cohort of 32?628 individuals (68.2% men; age, 45.6?±?7.4 years) without prevalent cardiovascular disease over a follow-up period of 26.6?±?7.5 years. RESULTS:: One thousand and fourteen persons (3.1%, 1.2 per 1000 person-years) had at least 1 hospitalization for orthostatic hypotension (n?=?462, 1.42%) or syncope (n?=?632, 1.94%). Orthostatic hypotension-related hospitalizations were predicted by age [per 1-year increase, hazard ratio 1.14, 95% confidence interval (CI): 1.12–1.16], smoking (hazard ratio 1.35, 95% CI: 1.12–1.64), diabetes (hazard ratio 1.50, 95% CI: 1.00–2.25), baseline orthostatic hypotension (hazard ratio 1.45, 95% CI: 1.05–1.98), in particular, by SBP fall at least 30?mmHg (hazard ratio 3.93, 95% CI: 2.14–7.23), whereas syncope hospitalizations by age (per 1-year increase, hazard ratio 1.09, 95% CI: 1.07–1.11), smoking (hazard ratio 1.27, 95% CI: 1.08–1.49), and hypertension (hazard ratio 1.42, 95% CI: 1.20–1.69). Both syncope-hospitalized and orthostatic hypotension hospitalized patients had higher burden of hospital admissions for other reasons such as cardiovascular, pulmonary, renal disease, or diabetes. During the follow-up, 10?727 (32.9%) died, with 419 deaths preceded by syncope/orthostatic hypotension hospitalization. After adjustment for traditional risk factors, syncope-hospitalization predicted all-cause mortality (hazard ratio 1.16, 95% CI: 1.02–1.31), whereas orthostatic hypotension hospitalization predicted cardiovascular mortality (hazard ratio 1.13, 95% CI: 1.07–1.19). CONCLUSION:: Hospital admissions due to syncope and orthostatic hypotension occur in ≈3% of older individuals and increase with age and comorbidities. Admissions due to syncope are associated with prevalent hypertension, whereas those due to orthostatic hypotension overlap with diabetes and previously identified orthostatic hypotension. Syncope-related admissions predict higher all-cause mortality, whereas orthostatic hypotension-related admissions herald increased cardiovascular mortality.</p>}},
author = {{Ricci, Fabrizio and Manzoli, Lamberto and Sutton, Richard and Melander, Olle and Flacco, Maria E. and Gallina, Sabina and de Caterina, Raffaele and Fedorowski, Artur}},
issn = {{0263-6352}},
language = {{eng}},
number = {{4}},
pages = {{776--783}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Hospital admissions for orthostatic hypotension and syncope in later life : insights from the Malmö Preventive Project}},
url = {{http://dx.doi.org/10.1097/HJH.0000000000001215}},
doi = {{10.1097/HJH.0000000000001215}},
volume = {{35}},
year = {{2017}},
}