HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma
Thuring, Camilla LU ; Follin, Elna LU ; Geironson Ulfsson, Linda LU ; Freyhult, Eva ; Junghans, Victoria LU ; Harndahl, Mikkel ; Buus, Søren and Paulsson, Kajsa M LU
(2015)
In British Journal of Cancer
113(6).
p.952-962
- Abstract
- Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7794194
- author
- Thuring, Camilla
LU
; Follin, Elna
LU
; Geironson Ulfsson, Linda
LU
; Freyhult, Eva
; Junghans, Victoria
LU
; Harndahl, Mikkel
; Buus, Søren
and Paulsson, Kajsa M
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HLA-I, tapasin, glioblastoma multiforme, peptide, tapasin-dependency, immunotherapy
- in
- British Journal of Cancer
- volume
- 113
- issue
- 6
- pages
- 952 - 962
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:26313662
- wos:000361499300012
- scopus:84941877555
- pmid:26313662
- ISSN
- 1532-1827
- DOI
- 10.1038/bjc.2015.297
- language
- English
- LU publication?
- yes
- id
- 106eb7a5-c9ba-42cd-baaa-a403dbb8ca57 (old id 7794194)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26313662?dopt=Abstract
- date added to LUP
- 2016-04-01 10:31:32
- date last changed
- 2022-04-27 22:58:40
@article{106eb7a5-c9ba-42cd-baaa-a403dbb8ca57,
abstract = {{Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.}},
author = {{Thuring, Camilla and Follin, Elna and Geironson Ulfsson, Linda and Freyhult, Eva and Junghans, Victoria and Harndahl, Mikkel and Buus, Søren and Paulsson, Kajsa M}},
issn = {{1532-1827}},
keywords = {{HLA-I; tapasin; glioblastoma multiforme; peptide; tapasin-dependency; immunotherapy}},
language = {{eng}},
number = {{6}},
pages = {{952--962}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma}},
url = {{http://dx.doi.org/10.1038/bjc.2015.297}},
doi = {{10.1038/bjc.2015.297}},
volume = {{113}},
year = {{2015}},
}