Attitudes to Stem Cell Therapy among Ischemic Stroke Survivors in the Lund Stroke Recovery Study
Aked, Joseph LU
; Delavaran, Hossein
LU
; Lindvall, Olle
LU
; Norrving, Bo
LU
; Kokaia, Zaal
LU
and Lindgren, Arne
LU
(2017)
In Stem Cells and Development
26(8).
p.566-572
- Abstract
Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors influencing this among stroke patients potentially suitable for SCT. Consecutive first-ever acute ischemic stroke patients aged 20-75 years with NIH stroke scale scores 1-18 were included. Exclusion criteria were severe comorbidities or infratentorial stroke. Clinical follow-up after 3-5 years assessed severity of residual stroke symptoms, cognitive function, functional status, patient-reported outcome, and comorbidity, and... (More)
Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors influencing this among stroke patients potentially suitable for SCT. Consecutive first-ever acute ischemic stroke patients aged 20-75 years with NIH stroke scale scores 1-18 were included. Exclusion criteria were severe comorbidities or infratentorial stroke. Clinical follow-up after 3-5 years assessed severity of residual stroke symptoms, cognitive function, functional status, patient-reported outcome, and comorbidity, and after receiving standardized information, the participants also completed an eight-item questionnaire on knowledge and attitudes about SCT. The relationships between clinical variables and positive attitude to SCT were assessed with logistic regression analyses. Of 108 patients included at baseline, 84 participated at follow-up and completed the questionnaire. In total, 12% had prior knowledge of SCT. When informed, 63% were positive toward it and 36% reported willingness to participate in SCT trials. Only 5%-8% expressed ethical considerations regarding different stem cell sources. Positive attitudes to SCT were associated with male gender (OR: 3.74; 95% CI: 1.45-9.61; P < 0.01) and better patient-reported outcome (OR: 1.02; 95% CI: 1.00-1.04; P < 0.05). In conclusion, stroke patients had limited prior knowledge of SCT, yet attitudes were positive among the majority after receiving standardized and neutral information. Gender and degree of stroke recovery may influence attitudes to SCT, indicating a need for targeted information to improve knowledge about SCT.
(Less)
- author
- Aked, Joseph
LU
; Delavaran, Hossein
LU
; Lindvall, Olle
LU
; Norrving, Bo
LU
; Kokaia, Zaal
LU
and Lindgren, Arne
LU
- organization
- publishing date
- 2017-04-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- patient attitude, stem cell therapy, Stroke
- in
- Stem Cells and Development
- volume
- 26
- issue
- 8
- pages
- 7 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:28142330
- wos:000398446500003
- scopus:85017296519
- ISSN
- 1547-3287
- DOI
- 10.1089/scd.2016.0343
- language
- English
- LU publication?
- yes
- id
- 7a098c8c-64e4-4d14-9a47-353648bbe2e1
- date added to LUP
- 2017-05-04 16:45:38
- date last changed
- 2024-01-13 20:07:16
@article{7a098c8c-64e4-4d14-9a47-353648bbe2e1,
abstract = {{<p>Preclinical studies suggest that stem cell therapy (SCT) may improve poststroke recovery, and clinical trials investigating safety are ongoing. However, knowledge about patients' attitudes to SCT in stroke is limited. We evaluated the knowledge and attitudes to this therapeutic approach as well as possible factors influencing this among stroke patients potentially suitable for SCT. Consecutive first-ever acute ischemic stroke patients aged 20-75 years with NIH stroke scale scores 1-18 were included. Exclusion criteria were severe comorbidities or infratentorial stroke. Clinical follow-up after 3-5 years assessed severity of residual stroke symptoms, cognitive function, functional status, patient-reported outcome, and comorbidity, and after receiving standardized information, the participants also completed an eight-item questionnaire on knowledge and attitudes about SCT. The relationships between clinical variables and positive attitude to SCT were assessed with logistic regression analyses. Of 108 patients included at baseline, 84 participated at follow-up and completed the questionnaire. In total, 12% had prior knowledge of SCT. When informed, 63% were positive toward it and 36% reported willingness to participate in SCT trials. Only 5%-8% expressed ethical considerations regarding different stem cell sources. Positive attitudes to SCT were associated with male gender (OR: 3.74; 95% CI: 1.45-9.61; P < 0.01) and better patient-reported outcome (OR: 1.02; 95% CI: 1.00-1.04; P < 0.05). In conclusion, stroke patients had limited prior knowledge of SCT, yet attitudes were positive among the majority after receiving standardized and neutral information. Gender and degree of stroke recovery may influence attitudes to SCT, indicating a need for targeted information to improve knowledge about SCT.</p>}},
author = {{Aked, Joseph and Delavaran, Hossein and Lindvall, Olle and Norrving, Bo and Kokaia, Zaal and Lindgren, Arne}},
issn = {{1547-3287}},
keywords = {{patient attitude; stem cell therapy; Stroke}},
language = {{eng}},
month = {{04}},
number = {{8}},
pages = {{566--572}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Stem Cells and Development}},
title = {{Attitudes to Stem Cell Therapy among Ischemic Stroke Survivors in the Lund Stroke Recovery Study}},
url = {{http://dx.doi.org/10.1089/scd.2016.0343}},
doi = {{10.1089/scd.2016.0343}},
volume = {{26}},
year = {{2017}},
}