Separation of pathogenic bacteria by chain length
Beech, Jason P. LU ; Ho, Bao Dang LU ; Garriss, Geneviève ; Oliveira, Vitor ; Henriques-Normark, Birgitta and Tegenfeldt, Jonas O. LU
(2018)
In Analytica Chimica Acta
1000.
p.223-231
- Abstract
Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease. Separation of cultured pneumococci into subpopulations based on morphological type (single cocci, diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, we present separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains... (More)
Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease. Separation of cultured pneumococci into subpopulations based on morphological type (single cocci, diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, we present separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.
(Less)
- author
- Beech, Jason P.
LU
; Ho, Bao Dang
LU
; Garriss, Geneviève
; Oliveira, Vitor
; Henriques-Normark, Birgitta
and Tegenfeldt, Jonas O.
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bacterial virulence, Deterministic lateral displacement, Morphology, Separation
- in
- Analytica Chimica Acta
- volume
- 1000
- pages
- 223 - 231
- publisher
- Elsevier
- external identifiers
-
- scopus:85036624788
- pmid:29289314
- ISSN
- 0003-2670
- DOI
- 10.1016/j.aca.2017.11.050
- language
- English
- LU publication?
- yes
- id
- 7b6dc176-45fc-4b79-87de-41103dc3ce7d
- date added to LUP
- 2018-01-02 12:46:45
- date last changed
- 2024-03-18 01:09:01
@article{7b6dc176-45fc-4b79-87de-41103dc3ce7d,
abstract = {{<p>Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease. Separation of cultured pneumococci into subpopulations based on morphological type (single cocci, diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, we present separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.</p>}},
author = {{Beech, Jason P. and Ho, Bao Dang and Garriss, Geneviève and Oliveira, Vitor and Henriques-Normark, Birgitta and Tegenfeldt, Jonas O.}},
issn = {{0003-2670}},
keywords = {{Bacterial virulence; Deterministic lateral displacement; Morphology; Separation}},
language = {{eng}},
pages = {{223--231}},
publisher = {{Elsevier}},
series = {{Analytica Chimica Acta}},
title = {{Separation of pathogenic bacteria by chain length}},
url = {{http://dx.doi.org/10.1016/j.aca.2017.11.050}},
doi = {{10.1016/j.aca.2017.11.050}},
volume = {{1000}},
year = {{2018}},
}