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Two allotypes of factor IX present in haemophilia B

Ljung, R. LU orcid ; Wallmark, A. LU and Nilsson, Inga Marie (1986) In Scandinavian Journal of Haematology 37(5). p.411-416
Abstract

Factor IX antigen (IX:Ag) was measured with three different immunoradiometric assays (IRMAs) in 30 healthy people and 43 patients with haemophilia B of varying severity. Two of the IRMAs were based on monoclonal antibodies capable of differentiating between two genetically determined molecular variants of normal factor IX. Most patients with severe hemophilia B lacked demonstrable IX:Ag. The factor IX variant that is undetectable with one of the monoclonal antibodies used was present in 2 out of 6 families with moderate haemophilia B and in 1 out of 6 families with mild haemophilia B. The existence of allotypes of factor IX in hemophilia B may have practical implications for carrier detection and prenatal diagnosis.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Scandinavian Journal of Haematology
volume
37
issue
5
pages
411 - 416
publisher
Wiley-Blackwell
external identifiers
  • pmid:3810038
  • scopus:0022862160
ISSN
0036-553X
DOI
10.1111/j.1600-0609.1986.tb02629.x
language
English
LU publication?
yes
id
7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef
date added to LUP
2016-10-26 13:54:58
date last changed
2024-01-04 14:59:24
@article{7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef,
  abstract     = {{<p>Factor IX antigen (IX:Ag) was measured with three different immunoradiometric assays (IRMAs) in 30 healthy people and 43 patients with haemophilia B of varying severity. Two of the IRMAs were based on monoclonal antibodies capable of differentiating between two genetically determined molecular variants of normal factor IX. Most patients with severe hemophilia B lacked demonstrable IX:Ag. The factor IX variant that is undetectable with one of the monoclonal antibodies used was present in 2 out of 6 families with moderate haemophilia B and in 1 out of 6 families with mild haemophilia B. The existence of allotypes of factor IX in hemophilia B may have practical implications for carrier detection and prenatal diagnosis.</p>}},
  author       = {{Ljung, R. and Wallmark, A. and Nilsson, Inga Marie}},
  issn         = {{0036-553X}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{411--416}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Scandinavian Journal of Haematology}},
  title        = {{Two allotypes of factor IX present in haemophilia B}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0609.1986.tb02629.x}},
  doi          = {{10.1111/j.1600-0609.1986.tb02629.x}},
  volume       = {{37}},
  year         = {{1986}},
}