Why Do Sex Chromosomes Stop Recombining?
Ponnikas, Suvi LU ; Sigeman, Hanna LU ; Abbott, Jessica K. LU
and Hansson, Bengt
LU
(2018)
In Trends in Genetics
34(7).
p.492-503
- Abstract
It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including... (More)
It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including modelling, population genomics, comparative approaches, and experiments) to disentangle the different hypotheses of sex chromosome evolution.
(Less)
- author
- Ponnikas, Suvi
LU
; Sigeman, Hanna
LU
; Abbott, Jessica K.
LU
and Hansson, Bengt
LU
- organization
- publishing date
- 2018-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- heterozygote advantage, meiotic drive, recombination suppression, sex chromosome, sex determination, sexual antagonism
- in
- Trends in Genetics
- volume
- 34
- issue
- 7
- pages
- 492 - 503
- publisher
- Elsevier
- external identifiers
-
- scopus:85046168465
- pmid:29716744
- ISSN
- 0168-9525
- DOI
- 10.1016/j.tig.2018.04.001
- language
- English
- LU publication?
- yes
- id
- 7ddedc60-1598-42d4-a3b8-ce7839981d16
- date added to LUP
- 2018-05-15 14:09:39
- date last changed
- 2024-04-01 05:39:07
@article{7ddedc60-1598-42d4-a3b8-ce7839981d16,
abstract = {{<p>It is commonly assumed that sex chromosomes evolve recombination suppression because selection favours linkage between sex-determining and sexually antagonistic genes. However, although the role of sexual antagonism during sex chromosome evolution has attained strong support from theory, experimental and observational evidence is rare or equivocal. Here, we highlight alternative, often neglected, hypotheses for recombination suppression on sex chromosomes, which invoke meiotic drive, heterozygote advantage, and genetic drift, respectively. We contrast the hypotheses, the situations when they are likely to be of importance, and outline why it is surprisingly difficult to test them. Lastly, we discuss future research directions (including modelling, population genomics, comparative approaches, and experiments) to disentangle the different hypotheses of sex chromosome evolution.</p>}},
author = {{Ponnikas, Suvi and Sigeman, Hanna and Abbott, Jessica K. and Hansson, Bengt}},
issn = {{0168-9525}},
keywords = {{heterozygote advantage; meiotic drive; recombination suppression; sex chromosome; sex determination; sexual antagonism}},
language = {{eng}},
number = {{7}},
pages = {{492--503}},
publisher = {{Elsevier}},
series = {{Trends in Genetics}},
title = {{Why Do Sex Chromosomes Stop Recombining?}},
url = {{http://dx.doi.org/10.1016/j.tig.2018.04.001}},
doi = {{10.1016/j.tig.2018.04.001}},
volume = {{34}},
year = {{2018}},
}