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Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.

Nilsson, Emma A LU orcid ; Matte, Ashok ; Perfilyev, Alexander LU orcid ; de Mello, Vanessa D ; Käkelä, Pirjo ; Pihlajamäki, Jussi and Ling, Charlotte LU orcid (2015) In Journal of Clinical Endocrinology and Metabolism 100(11). p.1491-1501
Abstract
Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
100
issue
11
pages
1491 - 1501
publisher
Oxford University Press
external identifiers
  • pmid:26418287
  • wos:000364925700023
  • scopus:84958673442
  • pmid:26418287
ISSN
1945-7197
DOI
10.1210/jc.2015-3204
language
English
LU publication?
yes
id
9b192333-b505-4b12-acf4-5e88c7f6277c (old id 8034507)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26418287?dopt=Abstract
date added to LUP
2016-04-01 10:32:54
date last changed
2023-03-17 06:27:02
@article{9b192333-b505-4b12-acf4-5e88c7f6277c,
  abstract     = {{Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.}},
  author       = {{Nilsson, Emma A and Matte, Ashok and Perfilyev, Alexander and de Mello, Vanessa D and Käkelä, Pirjo and Pihlajamäki, Jussi and Ling, Charlotte}},
  issn         = {{1945-7197}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1491--1501}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Clinical Endocrinology and Metabolism}},
  title        = {{Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.}},
  url          = {{http://dx.doi.org/10.1210/jc.2015-3204}},
  doi          = {{10.1210/jc.2015-3204}},
  volume       = {{100}},
  year         = {{2015}},
}