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The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.

Kozarcanin, Huda ; Lood, Christian LU ; Munthe-Fog, Lea ; Sandholm, Kerstin ; Hamad, Osama A ; Bengtsson, Anders LU ; Skjoedt, Mikkel-Ole ; Huber-Lang, Markus ; Garred, Peter and Ekdahl, Kristina N , et al. (2016) In Journal of Thrombosis and Haemostasis 14(3). p.531-545
Abstract
The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet identified mechanisms involved in triggering activation of the LP during thrombotic reactions.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thrombosis and Haemostasis
volume
14
issue
3
pages
531 - 545
publisher
Wiley-Blackwell
external identifiers
  • pmid:26614707
  • scopus:84960100143
  • wos:000372525100015
  • pmid:26614707
ISSN
1538-7933
DOI
10.1111/jth.13208
language
English
LU publication?
yes
id
1ec9af7f-f899-4a2f-84cc-24c19d7291a8 (old id 8234312)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26614707?dopt=Abstract
date added to LUP
2016-04-04 08:41:44
date last changed
2022-04-23 17:48:34
@article{1ec9af7f-f899-4a2f-84cc-24c19d7291a8,
  abstract     = {{The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet identified mechanisms involved in triggering activation of the LP during thrombotic reactions.}},
  author       = {{Kozarcanin, Huda and Lood, Christian and Munthe-Fog, Lea and Sandholm, Kerstin and Hamad, Osama A and Bengtsson, Anders and Skjoedt, Mikkel-Ole and Huber-Lang, Markus and Garred, Peter and Ekdahl, Kristina N and Nilsson, Bo}},
  issn         = {{1538-7933}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{531--545}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Thrombosis and Haemostasis}},
  title        = {{The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.}},
  url          = {{http://dx.doi.org/10.1111/jth.13208}},
  doi          = {{10.1111/jth.13208}},
  volume       = {{14}},
  year         = {{2016}},
}