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The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype

Cortez, Daniel LU ; Svensson, Anneli ; Carlson, Jonas LU orcid ; Graw, Sharon ; Sharma, Nandita ; Brun, Francesca ; Spezzacatene, Anita ; Mestroni, Luisa and Platonov, Pyotr G. LU (2018) In Journal of Electrocardiology 51(6). p.1003-1008
Abstract

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years,... (More)

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years, 65.2%male). Only the S-wave angle differentiated −ECG ARVD/C patients from controls (<0.001) with AU the ROC curve of 0.77 (95%CI 0.53 to 0.71) and odds ratio of 28.3 (95%CI 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arrhythmogenic right ventricular cardiomyopathy, Cascade screening, ECG, S-wave angle
in
Journal of Electrocardiology
volume
51
issue
6
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:30497719
  • scopus:85052642550
ISSN
0022-0736
DOI
10.1016/j.jelectrocard.2018.08.009
language
English
LU publication?
yes
id
83e951eb-95da-4b78-b958-6f0269d15846
date added to LUP
2018-09-25 08:12:13
date last changed
2024-01-15 01:55:10
@article{83e951eb-95da-4b78-b958-6f0269d15846,
  abstract     = {{<p>Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared to controls. Electrocardiogram measures of QRS duration, corrected QT interval, and measured angle between the upslope and downslope of the S-wave in V2, were assessed. Results: Definite ARVD/C was present in 155 patients (42.7 ± 17.3 years, 68.4%male). −ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.8 ± 17.6 years, 65.2%male). Only the S-wave angle differentiated −ECG ARVD/C patients from controls (&lt;0.001) with AU the ROC curve of 0.77 (95%CI 0.53 to 0.71) and odds ratio of 28.3 (95%CI 6.4 to 125.5). Conclusion: ARVD/C may lead to development of subtle ECG abnormalities distinguishable using the S-wave angle prior to development of 2010 Taskforce ECG criteria.</p>}},
  author       = {{Cortez, Daniel and Svensson, Anneli and Carlson, Jonas and Graw, Sharon and Sharma, Nandita and Brun, Francesca and Spezzacatene, Anita and Mestroni, Luisa and Platonov, Pyotr G.}},
  issn         = {{0022-0736}},
  keywords     = {{Arrhythmogenic right ventricular cardiomyopathy; Cascade screening; ECG; S-wave angle}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  pages        = {{1003--1008}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Electrocardiology}},
  title        = {{The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype}},
  url          = {{http://dx.doi.org/10.1016/j.jelectrocard.2018.08.009}},
  doi          = {{10.1016/j.jelectrocard.2018.08.009}},
  volume       = {{51}},
  year         = {{2018}},
}