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Survival in familial and non-familial breast cancer by age and stage at diagnosis.

Kharazmi, Elham ; Försti, Asta LU ; Sundquist, Kristina LU and Hemminki, Kari LU (2016) In European Journal of Cancer 52. p.10-18
Abstract
We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR:... (More)
We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0-3.7) or multiple (HR: 2.4-7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (>40). Young familial BC patients (age <40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer
volume
52
pages
10 - 18
publisher
Elsevier
external identifiers
  • pmid:26630529
  • wos:000367031000001
  • scopus:84948406634
  • pmid:26630529
ISSN
1879-0852
DOI
10.1016/j.ejca.2015.09.015
language
English
LU publication?
yes
id
46183124-4406-4cbf-95d0-a9bc8180c00a (old id 8505749)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26630529?dopt=Abstract
date added to LUP
2016-04-01 10:54:40
date last changed
2022-04-20 07:21:11
@article{46183124-4406-4cbf-95d0-a9bc8180c00a,
  abstract     = {{We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling &gt;14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (&gt;40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age &lt;40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0-3.7) or multiple (HR: 2.4-7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (&gt;40). Young familial BC patients (age &lt;40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC.}},
  author       = {{Kharazmi, Elham and Försti, Asta and Sundquist, Kristina and Hemminki, Kari}},
  issn         = {{1879-0852}},
  language     = {{eng}},
  pages        = {{10--18}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Cancer}},
  title        = {{Survival in familial and non-familial breast cancer by age and stage at diagnosis.}},
  url          = {{http://dx.doi.org/10.1016/j.ejca.2015.09.015}},
  doi          = {{10.1016/j.ejca.2015.09.015}},
  volume       = {{52}},
  year         = {{2016}},
}