GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats
(2009) In Pharmacology, Biochemistry and Behavior 91(3). p.409-416- Abstract
- The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 μg/rat) reduced the expression of morphine CPP whereas the dose of 6 μg/rat of the drug increased it. Baclofen also significantly... (More)
- The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 μg/rat) reduced the expression of morphine CPP whereas the dose of 6 μg/rat of the drug increased it. Baclofen also significantly reduced the acquisition of morphine CPP in morphine-sensitized animals. Administration of GABAB receptor antagonist, CGP 35348, significantly reduced the expression (12 μg/rat) and acquisition (1.5, 6 and 12 μg/rat) of morphine CPP in morphine-sensitized animals.
In conclusion, results confirmed the importance of GABAB receptors within the ventral tegmental area of morphine CPP in morphine-sensitized female rats. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8569564
- author
- Sahraei, Hedayat ; Etemadi, Leila LU ; Rostami, Parvin ; Pourmotabbed, Ali ; Zarrindast, Mohammad-Reza ; Shams, Jamal ; Ghoshooni, Hassan ; Noroozzadeh, Ali ; Esfandiari, Behnaz and Hossein, Seyed
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sensitization, Morphine, GABAB receptor subtypes, Conditioned place preference, Rat
- in
- Pharmacology, Biochemistry and Behavior
- volume
- 91
- issue
- 3
- pages
- 409 - 416
- publisher
- Elsevier
- external identifiers
-
- scopus:57449102153
- pmid:18789350
- ISSN
- 1873-5177
- DOI
- 10.1016/j.pbb.2008.08.015
- language
- English
- LU publication?
- no
- id
- ab9f354e-9b25-49e9-a447-a9175551fe00 (old id 8569564)
- date added to LUP
- 2016-04-01 12:30:34
- date last changed
- 2022-02-03 23:07:21
@article{ab9f354e-9b25-49e9-a447-a9175551fe00,
abstract = {{The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 μg/rat) reduced the expression of morphine CPP whereas the dose of 6 μg/rat of the drug increased it. Baclofen also significantly reduced the acquisition of morphine CPP in morphine-sensitized animals. Administration of GABAB receptor antagonist, CGP 35348, significantly reduced the expression (12 μg/rat) and acquisition (1.5, 6 and 12 μg/rat) of morphine CPP in morphine-sensitized animals.<br/><br>
In conclusion, results confirmed the importance of GABAB receptors within the ventral tegmental area of morphine CPP in morphine-sensitized female rats.}},
author = {{Sahraei, Hedayat and Etemadi, Leila and Rostami, Parvin and Pourmotabbed, Ali and Zarrindast, Mohammad-Reza and Shams, Jamal and Ghoshooni, Hassan and Noroozzadeh, Ali and Esfandiari, Behnaz and Hossein, Seyed}},
issn = {{1873-5177}},
keywords = {{Sensitization; Morphine; GABAB receptor subtypes; Conditioned place preference; Rat}},
language = {{eng}},
number = {{3}},
pages = {{409--416}},
publisher = {{Elsevier}},
series = {{Pharmacology, Biochemistry and Behavior}},
title = {{GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats}},
url = {{http://dx.doi.org/10.1016/j.pbb.2008.08.015}},
doi = {{10.1016/j.pbb.2008.08.015}},
volume = {{91}},
year = {{2009}},
}