Novel insights in drug metabolism by MS imaging.
(2016) In Bioanalysis 8(6). p.575-588- Abstract
- During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8821635
- author
- Sugihara, Yutaka LU ; Watanabe, Ken-ichi and Végvári, Ákos LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Drug Metabolism and Mass Spectrometry Imaging
- in
- Bioanalysis
- volume
- 8
- issue
- 6
- pages
- 575 - 588
- publisher
- Future Science
- external identifiers
-
- pmid:26915978
- scopus:84960399327
- wos:000373234900009
- pmid:26915978
- ISSN
- 1757-6180
- DOI
- 10.4155/bio-2015-0020
- language
- English
- LU publication?
- yes
- id
- 12d66dcf-34ab-4476-ae64-d0be2f55e775 (old id 8821635)
- date added to LUP
- 2016-04-01 10:04:20
- date last changed
- 2022-02-02 06:06:02
@article{12d66dcf-34ab-4476-ae64-d0be2f55e775, abstract = {{During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.}}, author = {{Sugihara, Yutaka and Watanabe, Ken-ichi and Végvári, Ákos}}, issn = {{1757-6180}}, keywords = {{Drug Metabolism and Mass Spectrometry Imaging}}, language = {{eng}}, number = {{6}}, pages = {{575--588}}, publisher = {{Future Science}}, series = {{Bioanalysis}}, title = {{Novel insights in drug metabolism by MS imaging.}}, url = {{http://dx.doi.org/10.4155/bio-2015-0020}}, doi = {{10.4155/bio-2015-0020}}, volume = {{8}}, year = {{2016}}, }