Exploring the multifaceted nature of the common lymphoid progenitor compartment.
(2016) In Current Opinion in Immunology 39. p.121-126- Abstract
- While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates... (More)
- While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8825669
- author
- Jensen, Christina LU ; Strid, Tobias and Sigvardsson, Mikael LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Immunology
- volume
- 39
- pages
- 121 - 126
- publisher
- Elsevier
- external identifiers
-
- pmid:26871596
- scopus:84957539728
- wos:000373866000019
- pmid:26871596
- ISSN
- 1879-0372
- DOI
- 10.1016/j.coi.2016.01.009
- language
- English
- LU publication?
- yes
- id
- 7ddf8e05-ae74-48c7-bbed-94a1c8661dbd (old id 8825669)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26871596?dopt=Abstract
- date added to LUP
- 2016-04-04 09:37:19
- date last changed
- 2022-04-23 21:28:12
@article{7ddf8e05-ae74-48c7-bbed-94a1c8661dbd,
abstract = {{While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.}},
author = {{Jensen, Christina and Strid, Tobias and Sigvardsson, Mikael}},
issn = {{1879-0372}},
language = {{eng}},
pages = {{121--126}},
publisher = {{Elsevier}},
series = {{Current Opinion in Immunology}},
title = {{Exploring the multifaceted nature of the common lymphoid progenitor compartment.}},
url = {{http://dx.doi.org/10.1016/j.coi.2016.01.009}},
doi = {{10.1016/j.coi.2016.01.009}},
volume = {{39}},
year = {{2016}},
}